117 



-19^2- 



338c CHASIS, H., GOLDRING, W. and SMITH, H, 



Reduction of blood pressure associated with pyrogenic reaction 

 in hypertensive subjects 



J, Clin. Invest, 21:369-376, 19^2 



No inherent vasodilator or depressor activity is known to 

 reside in pyrogens, and the vasomotor responses noted are 

 believed to be complex. The initial pressor phase is character- 

 ized by vasoconstriction, probably neurogenic in origin; systolic 

 and diastolic pressures are moderately reduced shortly there- 

 after. A dual activity in pyrogens is suggested by the fact 

 that the temperature rise may be blocked without altering the 

 hypotensive action and renal vasodilation. Premedication with 

 amidopyrine allows the hypotensive effect to be applied in 

 hypertensive states, without a corresponding increase in body 

 temperature c The delayed activity of the second phase of the 

 hypotensive cycle after administration of pyrogens may, if 

 dosage is not controlled, produce alarming circulatory crises. 



339. CO TUI, and SCHRIPT, M. H. 



A tentative test for pyrogens in infusion fluid 



Proc. Soc. Exper. Biol. Med, 49; 320-323 ■, 19^2 



These Investigators used, with success, a procedure which 

 eliminated some of the errors commonly encountered in pyrogenic 

 testing. Since the rabbit is responsive to other substances 

 and has a highly labile thermoregulatory mechanism, the lack 

 of response to pyrogen injection has more significance than 

 the positive test. The dog is less sensitive to pyrogenic: 

 materials; hence positive pyrogenic reactions in this animal 

 are highly significants Preliminary tests on the rabbit 

 are confirmed through injection of a test dose in the dog. 

 The test dose Is graduated according to the sensitivity dis- 

 played. The rabbit is 3 times, the dog 6 times less sensitive 

 than human beings. In 214 tests, clinical and laboratory 

 data have been in agreement, 



340. CO TUI and SCHRIPT, M. H. 



Production of pyrogen by some bacteria 



J, Lab. Clin. Med. 27 "569-575^ 1942 



In a study of pyrogen production in 18 strains of micro-organ- 

 isms, representative of different genera, families and species 



