118 



-19^2- 



pyirogen production was found to be common to many types of 

 bacteria o It was not confined to organisms found in water, and 

 was not associated with nucleic acid, with lack of affinity for 

 the gram stain, pathogenicity, chromatin production, nor was 

 it confined to lower biologic forms. Saceharomyces Fink wild 

 yeast produces pyrogen. In this study, a new criterian was em- 

 ployed in the Judgment of toxicity; the production of antibodies 

 in experimental animals. 



3^1. CO TTJI and WRIGHT, A. M. 



The preparation of non-pyrogenlc infusion^. and other intravenous 

 fluids by adsorptive filtration 



Ann, SuPg. 116:412-^25, 19^2 



The adsorptive filtration method, and a standardized apparatus, 

 have been adopted for the production of non-pyrogenlc physiolo- 

 gic salt, dextrose and sodium citrate solutions. The use of 

 calibrated asbestos filter pads is a feature of the method. 



3^2. DELATMAY, A. 



Recherche des constituents bacterlens responsables de I'appel 

 leucocytalre (Investigation of bacterial constituents re- 

 sponsible for the leukocyte response) 



Ann. Insto Pasteur, 68:72-74, 1942 



Marked leukocytic response was produced by an autolysate of 

 s t a phy lo cocci . Dealburalnized autolysates yielded an active, 

 specific polysaccharide, capable of affecting the leukocyte 

 count In concentrations ranging between 0.001 and 1.0 mg. The 

 physiologic carbohydrate content is directly concerned In the 

 stimulation of leukocyte production. Chemotaxis may be in- 

 volved but this was not verified by a comparison with glycogen. 

 Similar activity is shown by preparations prepared from ty- 

 phoid, colon, paratyphoid B and Shiga organisms. It is believed 

 that the active principle Ts a specific glucldo -lipid antigen, 

 since local leukocyte response follows the injection of small 

 quantities of the substance beneath the skin. 



343. DIBOS, R. J., HOBERMAN, H. D. and PIERCE, C. 



Some factors affecting the toxicity of cultures of Shigella 

 dysenteriae 



