119 



-19^2- 



Proc. Nat. Acad. Scl. 28:^^53, 19^2 



Conditions which favor aerobic metabolism greatly increase the 

 toxicity of the cells in S. dysenteriae cultures, as well as 

 the yield of dry material. When 1,5 mg, of cells grown under 

 anaerobic conditions were injected into mice, all survived; 

 0.1 mg. of cells grown on silica gel plates killed all mice. 

 Glucose in silica gel medium decreased the toxicity of cells. 

 'Smooth' and 'rough' varieties were similarly affected by 

 environmental growth conditions. The toxic pi'lnciple was 

 bound to the cell 'itself and released in solution through 

 autolysis. It was vjater soluble, stable and resistant to 

 proteolysis . 



344. DUGGAN, W. F. 



Choroiditis centralis serosa: Diagnosis, patholgic physiology 

 and therapy 



Arch. Ophthalmol. 27:123-133, 19^2 



Bacterial body cellular elements and toxins produce a local 

 ischemic condition after injection. As this is overcome by 

 pyrexial factors, oxygen is increased in the area with bene- 

 ficial effects. 



345. FAVORITE, G, 0. and MORGAN, H, R. 



Effects produced by the intravenous injection in man of a toxic 

 antigenic material derived from. Eberthella typhosa : Clinical, 

 hematological, chemical and serological studies 



J, Clin. Invest. 21:589-599, 19^2 



No marked changes in the total protein, urea nitrogen, creati- 

 nine, chloride, glucose and C02-comblning power of blood appeared 

 after a purified antigenic material obtained from E. typhosa 

 was administered to human beings with neurosyphilis. Repeated 

 injections produced antibodies in high titer. The leukopenia 

 and leukocytosis usually noted after pyrogen Injections were 

 present. The sedimentation rate rose after each injection. 

 In animals receiving Intravascular injections of this substance, 

 pathologic changes involving heart muscle, lung, liver and 

 spleen tissue, the bone marrow and vascular bed were produced. 



