123 

 -19^2- 



355. NECHELES, H,, DOMMERS, P», WEINER, M„, OLSON, Wo Ho and 

 RYCHEL, Wo M. 



Depression of gastric motility without elevation of body tem- 

 perature following the injection of pyrogen 



Am, J. Physiolo 137:22-29, 19^2 



Pentnucleotide, yeast or thymus nucleic acid, peptone, B« coll 

 vaccine or triple typhoid vaccine, a bacterial pyrogen, and tap 

 water were administered in subfebrlle doses into unanesthetized 

 fasting dogs in which continuous gastric motility had been pro- 

 duced by prostigmlnee Pentnucleotide inhibited gaatric motility 

 in all tests. The average duration of activity was 30 minutes. 

 Yeast nucleic acid had deep depressive effects, thym$c nucleic 

 acid none. Peptone, 5 and 50 mg., neither affected temperature 

 nor motility, B, coll vaccine (12-1/2 million organisms) 

 depressed gastrTc motility. The pyrogenic preparation depressed 

 gastric motility profoundly. 



356. OLITZKI, L., AVINERI-SHAPIRO, S. and KOCH, Po K, 



The hypothermic and adreno -hemorrhagic effects of bacterial 

 vaccines 



J. Immunol. 45:237-248, 19^2 



A large number of vaccines from a variety of bacterial species 

 were tested for the following: hypothermic effects, adreno- 

 heraorrhagic effectsj nonspecific resistance through treatment 

 with bacterial vaccines; nonspecific resistance through treat- 

 ment with serum or plasma, heterologous or homologous; active 

 and passive immunization. 



Adreno -hemorrhagic, hypothermic and leukopenic reactions 

 appeared to be associated and were produced only by vaccines 

 from certain organisms, in the main, the gram-negative groups. 

 Reactions were varied in intensity and occurrence and influenced 

 by such nonspecific factors as amounts, age and weight of exper- 

 imental animals^ and the species. Normal serum or plasma pro- 

 duced a resistant period extending 2 to 3 days, vaccine, for 12 

 days. However, vaccine prevented leukopenia after injection 

 of bacterial products for two days only. It did not protect 

 against the adreno -hemorrhagic effects, nor did passive 

 immunization. 



