127 



-19^3- 



The leukopenic factor has been sought In E. typhosa ♦ It has 

 been considered to be nonprotein (Morgan); the Molisch reaction 

 is positive. Trichloracetic extracts of bacterial preparations 

 produce leukopenia on injection. 



367. DELAUNEY, A„ 



Mise en evidence d ' une nouvelle proprlete des antig^nes glucido- 

 lipidiques; Leur pouvoir leucop^eant (A new property of glu- 

 cido-lipid antigens: Their leukopenic ability) 



Compt. rend. Soc , biol. 137:589-590, 19^3 



A new property of antigens^ the leukopenia -producing ability, 

 appears when lethal doses of glucido-lipid antigens from colon 

 or typhoid organisms are administered. The leukocyte count 

 is depressed within one hour (from 10,000 to 25,000 initially 

 to 5*000 or less). This is an early sign of intoxication. 

 The leukocyte index is balanced by the increased mononuclear 

 cells. In about 3 hours, the white cells increase. With more 

 moderate dosages, the return to normal levels begins in 24 

 hours. Minute (gamma) dosages bring an early leukocytosis; 

 the animal so treated remains in perfect health. This stim- 

 ulation is believed to be a cheraotactic one. According to J. 

 Jolly, leukopenia occurs when leukocytes are retained in viscera, 

 liver, lung and spleen - only small numbers remain in tissues. 

 Glucido-lipid antigens bring intravisceral mobilization as the 

 leukocytes migrate inward from the peripheral areas. 



368. EDELMANN, Ac, MAHANNA, D. L., LEWIS, L, A., THATCHER, J. S. 

 and HARTMAN, F. A, 



The use of adrenal extract in fever therapy 



J. Clin, Endocrinol. 3:20-27, 194-3 



369. GUERRA, P. and BARBOUR, H. G. 



The mechanism of aspirin antipyresis in monkeys 



J. Pharm. & Exper. Therap, 79:55-61, 1943 



In normal monkeys aspirin produces only a slight decrease in 

 temperature, but in fever produced by the subcutaneous inject- 

 ion of yeast, it induces vasodilation and perspiration. 



