130 



-19 4 3- 



375. KNIGHT, H. Co, EMORY, Mo L., and FLINT, L. D. 



A method of inducing therapeutic fever with typhoid vaccine 

 using the intravenous drip technltjue 



Vener. Dis. Inform. 24:323* 19^3 



The Infusion of a dilute solution of typhoid vaccine in 5 

 per cent glucose-saline permits control of fever levels with- 

 out danger to the patient. Over 1^00 5>atients with gonorrhea 

 of a resistant type were treated -by jaeans of an initial intra- 

 venous 'shock' dose of concentrated material, followed in 1 

 or 2 hours by intravenous slow Infusion. 



I 



376. HOROAN, flc R. 



Pathologic changes produced in ra'bblts by a toxic soiaatlc anti- 

 gen derived from Eberthella t:yph6sa 



Am. J, fathol, 19s 135-1^3, 19^3 



Marked inflammatory changes with later necrosis and fibrotic 

 'walling' of the area followed the injection in the skin of 

 somatic fever-producing antigen of E. typhosa . When injected 

 intravenously, it caused vascular damage and subsequent throm- 

 bosis, ne(Ji»o3is of hepatic cells and changes in heart muscle, 

 adrenals and bone marrow. The lymphoid tissue of the spleen 

 may be injured o Hyperplasia of bone marrow follows lYiJul?y to 

 the hematopoietic tissues. 



377. McCLOSKY^ Wo T., PR.ICE^ C. W., VAN WlNDLE, Wo, <m,, WELCH, H., 

 and CALVERY, H. 0. 



Results of the first U.S. P. Collaborative Study of pyrogens 



J. Am. Pharm. A. 32:69-73, 19^3 



Tolerance to the pyrogen from Ps. aeruginosa develops on repfe- 

 tition of injections over a c ons 1 d ei'abi e t Ime j with an inter- 

 vening rest period of thres weeks, the response phase is 

 restored. The selection of animals for the bio-assay is empha- 

 sized and a method outlined for shortening test periods. 



