133 



- 1 9 4 3 - 

 384. ZAHL, P. A. and BJERKNES, C „ 



Induction of decldua-placental hemorrhage in mice by the endo- 

 toxins of certain gram-negative bacteria 



Proc. Soc. Exper, Biol. & Med, 5^:329-332, 19^3 



Endotoxins of Shigella paradysenteriae Flexner , S. typhimurium , 

 and Rhodo spirillum rubrum were injected in mice intraperi- 

 toneally on the 12th to iSth day of gestation; one-fifth of 

 the LD50 dose was used. All mice responded with decidua- 

 placental hemorrhage c No other tissues were hemorrhagic. 



35. ZAHL, P. A. and HUTNER, S. H. 



Action of bacterial toxins on tumors. III. Some biological 

 properties of purified Salmonella typhimurium endotoxins 



Proc, Soc. Exper, Biol, ^c Med. 52:ll6-ll8, 19^3 



The object of this study was the determination of the activity 

 of the purified antigen in respect to lethality, hemorrhage 

 production in transplanted tumors and production of protective 



antibodies in mice. 



In three stages of purification, fractions were active for all 

 three of the above phenomena, 



386. ZAHL, P. A. HTJTNER, S, K. and COOPER, P. S. 



Action of bacterial toxins on tumors, V. Immunological pro- 

 tection against tumor hemorrhage 



Proc. Soc, Exper. Biol, & Med, 5^:48-50, 1943 



After immunizing doses of Shigella para dysenter lae (1/2 to 

 1 LDcq) were Injected intra perl toneally in mice for 6 days; 

 an Interval of 10 to I5 days was allowed before the implantation 

 of sarcoma I80. Seven days later hemorrhage-inducing doses of 

 Flexner endotoxin were administered. Non-immunized mice were 

 used as controls. 



Immunized animals showed no hemorrhage at dosages of endotoxin 

 below LD50' Controls were found to have tumor hemorrhage at 

 dosage ranging above 1/200 of the LDc-q. 



