135 



- 1 9 ^ ^ - 



redistilled water. Prom reservoir waters, two strains of or- 

 ganisms were isolated; one belonged to the Achromobacterlum 

 prodlgiosus group, the other, from the same species, produced 

 chromogenic cultures <. Both were aerobic, non-sporulating. 

 One was gram-positive. Culture suspensions produced fever, 

 but only insignificant decreases in the leukocyte count. 



90. BRUES, A, M. and SHEAR, M. J. 



Chemical treatment- of tumors X» Reactions of four patients with 

 advanced malignant tumors to injections of a polysaccharide 

 from Serratia marcescens culture 



J. Nat. Cancer Inst. 5:195-201, 19^^ 



Pour patients with inoperable tumors (Ewing's sarcoma, carcinoma 

 of the prostate, lymphosarcoma and myeloma) were given injections 

 of the hemorrhage-producing filtrate fraction prepared from 

 B. prodigiosus . Chills, transitory fever and leukocytosis 

 followedT No alterations were seen in multiple myeloma. There 

 was immediate pain in tumorous areas in Ewing's sarcoma and 

 carcinoma of the prostate; symptoms were somewhat relieved 

 for a short period therafter. In lymphosarcoma (the patient 

 was in extremis ) widespread destruction of tumor tissue followed 

 the injection, and a temporary remission occurred. All 

 patients died from malignancies. Post-mortem examination showed 

 evidences of hemorrhage in tumor tissue. 



The two patients who were temporarily benefited by therapy 

 developed high NPN and uric acid levels in the blood c One 

 patient excreted, on a low purine diet, 2500 mg. of uric acid 

 in the first 2H- hours after the injection. Some evidences of 

 congestive failure were noted in two patients. The toxic 

 response to uneliminated waste products is a serious medical 

 problem where rapid destruction of neoplastic tissue follows 

 chemotherapy, 



391. CAMPBELL, D. J. 



Gonorrhea in North Africa and the Central Mediterranean 



Britc M. J. 1:^4, 19^4 



Adjuvants to the standard treatment are necessary if results are 

 to be obtained in the intractable type of gonorrhea found in 

 North Africa and the Levant. The use of TAB vaccine has been 

 helpful. 



