136 



-19^^- 



392. CO TUI, HOPE, D., SCHRIFT, M. H., POWERS, J., WALLEN, A, and 

 SCHMIDT, Ll'"~ 



Purified pyrogen from Eberthella typhosa 



J. Lab. Clin. Med. 29:58-62, 1944 



A concentrate from a filtrate of E. typhosa was deproteinlzed . 

 It contained 1 glucosamine unit for every ^ or 6 hexose units. 

 Total hydrolysis gave a yield of 30 per cent for reducing 

 sugars; activity was destroyed. The minimum pyrogenic dosage 

 (MPD) was 0.06 micrograms per kg. for the rabbit, 0,24 for the 

 dog and 0.02 for man. The approximate lethal dose (for the 

 rabbit) lies between 175 and 190 micrograms per kg. 15 micro- 

 grams per kg. was a toxic dose for man. 



393. DELAUNAY, A,, SARCIRON, R. C, and PAGES, J. 



Antigenes glucido-lipidiques et pouvoir phagocytaire des 

 cellules reticuloendotheliales (Glucido-lipidic antigens and 

 phagocytic ability of reticuloendothelial cells) 



Compt. rendo Soc . biol, 138:345, 1944 



Sublethal doses of bacterial glycolipids from staphylococci 

 and the virulent bacillus of Charbon, provoked a sharp increase 

 resistance to bacterial invasion in the guinea pig and mouse. 

 This may be caused by a diminution in phagocyte mobility or 

 the preparations may act as reticuloendothelial toxins. A 

 'smooth' E. typhosa organism, viable, was mixed with trypan 

 blue or azoprotein and injected intravenously in the mouse. 

 The dosages ranged from 0.5 to O.OO5 mg. and was followed by 

 the glycolipid antigen. The reticuloendothelial cells, parti- 

 cularly the Kupfer cells, either contained dyes or the bacteria. 

 It was concluded that reticuloendothelial cellular elements 

 have no phagocytic power; if the antigen possessed the power 

 to lower resistance to bacterial invasion, it must have done 

 so through polynuclear diapedesis. 



394. PRANKE, P. E. 



Action of toxic doses of the polysaccharide from Serratia 

 marcescens ( Bacillus prodigiosus ) on the dog and guinea pig 



J, Nat, Cancer Inst. 5:185-193, 1944 



In this study a series of unanesthetized and anesthetized dogs, 

 and paired rats were given intravenous, intraperitoneal or 



