139 



_ 1 9 ^ 4 - 



Marked changes In leukocyte distribution in the blood of cows 

 with brucellosis appear within 6 to 7 hours after the intra- 

 cutaneous injection of the sonic filtrate of Brucella abortus . 

 A rise in immature (single-lobed) neutrophils is the raoi^ 

 significant feature, but the total white count remains ele- 

 vated for 48 hours o Leukocytosis is not seen in uninfected 

 animals. 



1^01. MENKIN, V. 



Chemical basis of fever 



Science 100:337-338, 1944 



Toxic pyrogens are released from cells after injury to their 

 structure in fever. ' Pyrexin.' , from the euglobulin fraction 

 of exudates in inflammatory processes, is a nitrogenous, 

 thermostable substance, non-toxic to mice. A non-pyrogenic, 

 proteolytic material, 'necrosin', is found in association 

 with 'pyrexin'; the latter may be a by-product of proteolysis. 

 When 'pyrexin' or crude euglobulin fractions are injected 

 into the marginal ear veins of the rabbit, an average increase 

 in body temperature of 2.7° F. follows within 1 or 2 hours. 



402. RITTER, W. L. and NUSSBAUM, M. A. 



Occupational illnesses in cotton industries. I. 'Cotton 

 Pever' . 



Mississippi Doct. 22:96, 1944 



The disease known as 'cotton fever', 'cotton cold', or 'card 

 room fever' is discussed with reference to its incidence in 

 Mississippi cotton factories. The illness. With its 

 characteristic symptoms, attacks new employees who work in 

 enclosed rooms and handle untreated cotton. First symptoms 

 appear within 24 hours after the employee begins work; fever, 

 headache, nausea and epistaxis usually disappear within a few 

 hours. The severity of the symptoms depends on the grade of 

 cotton handled and its dust concentration; continuous handling 

 within a given environment produces immunity to the infection. 

 Immunity is lost during exposure to lower grades of cotton, 

 prolonged absence from exposure and when the concentration 

 of cotton dust is increased. A bacterium, Aerobacter cloacae ^ 

 may be the causative organism. 



