141 



- 1 9 4 4 - 



SHEAR, M. J. and PERRAULT, A. 



Chemical treatment of tumors. IX. Reactions of mice with 

 primary subcutaneous tumors to Injection of a hemorrhage -pro- 

 ducing bacterial polysaccharide. 



J. Nat. Cancer Inst. 4:461-476, 1944 



Normal mice given small doses of a special preparation of the 

 polysaccharide from S. marcescens containing 100,000 m.t.u. 

 per cc, developed tolerance during the administration of 

 gradually Increasing doses and survived a single Injection 

 containing l6 times the LDcq dose. Tumor-bearing mice also 

 developed resistance to lethal effects of doses 13 times the 

 size of the LD50 for the tumor-bearing mouse. When tumors were 

 small or of medium size, dosages were tolerated which proved 

 fatal when Injected Into animals with large, extensive neo- 

 plastic growths. Where tumors were less than I5 mm. In diameter, 

 hemorrhage or necrosis was not observed. The degree of hem- 

 orrhage appears to depend on the size of the dose of poly- 

 saccharide. 



An adsorbent (aluminum hydroxide suspension) was precipitated 

 and used In the Injection of polysaccharide. Hemorrhage and 

 necrosis were regularly produced In tumors. 



TAYLOR, R. D. and PAGE, I. H. 



Studies on the mechanism of the hypotensive effect of sub- 

 stances eliciting leukocytosis and fever 



Am. J. Med. Sci. 208:281-290, 1944 



With a view toward practical therapeutic application, the 

 principles underlying relationships between leukocytosis, hypo- 

 tension and pyrogenic agents were studied in the dog with 

 experimental renal hypertension and in humans afflicted with 

 malignant hypertension. 



Leukocytosis was Induced in hypertensive dogs by subcutaneous 

 injection of turpentine, subcutaneous and Intraperitoneal 

 injection of sterile pus, intramuscular and intravenous in- 

 jection of the leukocyte-producing factor of Menkin and by 70 

 per cent acetylmethylaralne. Terminal malignant hypertension 

 in humans was treated by an albumin fraction from pork serum 

 containing the buffy layer of leukocytes and an extract of human 



