142 



-19 4 4- 



leukocytes precipitated by (NHif)2S0i.. Mean arterial pressure 

 of the ddg was not affected by aBei?Ile pufl, acetyltnethylamlne, 

 or by Menkln's leukocyte -producing factor. Consistent rer 

 ductlon of blood pressure was not secured In malignant hyper- 

 tensive patients; allergic factors were the only mechanlBtns 

 clearly Involved In the lower pressures achieved. The authors 

 suggest that 'non-specific' and Inflammatory reactions Impair 

 that function of the adrenal cortex which maintains vascular 

 reactivity and this may. In certain cases, bring a reduction 

 In arterial pressure. 



408. URBACH, E., GOLDBURGH, H. L. and GOTTLIEB, P. M. 



General Sanarelll-Shwartzman phenomenon with fatal outcome 

 following typhoid-vaccine therapy 



Ann. Int. Med. 20:989-994, 1944 



409. YOUNG, E. 0. and RICE, P. A. H. 



Leukocytosis as an Index of pyrogenlclty In fluids for Intra- 

 venous use 



J. Lab. Clin. Med. 29:735-741, 1944 



Leukocytosis was the most sensitive Index of response to pyro- 

 gens In the dog. Progressively less sensitive were neutrophilia, 

 leucopenla and hyperpyrexia. Leukocytosis was proportional to 

 the amount of pyrogen in more dilute solutions. The lowest 

 amount of pyrogen from Ps . aeruginosa required to produce a 

 positive leukocytic response in the dog contained O.056 gamma 

 of N. 



410. YOUNG, E. G. and HAWKINS, W. W, 



The role of pyrogens In the alleged leucocytlc response to 

 allantoln 



J. Pharmacol. & Exper. Therap. 81:10-16, 1944 



Allantoln In Ringer's solution produced leukocytosis and 

 neutrophilia In man when given subcutaneously or by the Intra- 

 venous route. Pyrogens, and not allantoln, w«re the res- 

 ponsible agents. 



