144 



-19^5- 



415. ALTSCHULE, M. D. and PREEDBERG, A. S. 



Circulation and respiration in fever 



Medicine 24:403-411, 1945 



The authors present a comprehensive summary of the mechanisms 

 involved in the cardiovascular and pulmonary manifestations 

 of endogenous infectious fever. Cardiorespiratory functions are 

 altered during the chill, and flush phases of fever, and during 

 defervescence. In the prodromal stage, no significant 

 physiologic or chemical changes occur. Sympathetic discharge 

 initiates the chill, producing generalized vasoconstriction^ 

 with circulatory stasis of varying degree. The cardiac output 

 falls, venous blood becomes deoxygenated, hence O2 consumption 

 increases. Body temperature rises. There is a possibility 

 that stasis in the respiratory center gives rise to hyper- 

 ventilation and the blood changes characteristic of allcalosis. 

 In the flush phase, marked vasodilatation, and increased cardiac 

 output precede the acceleration of circulation time. Arterio- 

 venous shunts open to permit equalization of blood pressure; 

 the sudden vasodilatation brings hypotension. Hyperventilation 

 diminishes. The circulation and respiration return to normal 

 limits during defervescence. 



416. ALTSCHULE, M. D., PREEDBERG, A. S. and McMANUS, M. J. 



Circulation and respiration during an episode of chill and 

 fever in man 



J. Clin. Invest. 24:878-889, 1945 



Observations on the changes following the administration of 

 a pyrogenic agent (typhoid vaccine) revealed the presence of 4 

 divisions in the febrile response: prodromal, chill phase, 

 flush phase, and defervescence. The phenomena associated 

 have been reviewed ( Medicine 24:403, 1945). It was noted 

 that lymphatic function was greatly increased during the flush 

 phase. 



417. BANDELIN, P. J. 



A leucocyte response to pyrogen in rabbits 



J. Am. Pharm. A. 34:48-51, I945 



In a search for a more reliable and sensitive method for pyro- 

 gen determination, the leucocyte response of the rabbit to 

 varying dilutions of pyrogen was selected as a standard of 

 reference. Similar changes occur after injection of distilled. 



