145 



-19 4 5- 



tap and river waters. The initial leucopenia may be considered 

 evidence of pyrogenicityj the secondary leukocytosis is corro- 

 borative. When used together they are considered to be more 

 sensitive indicators of the presence of pyrogen than are body 

 temperature elevations. In the rabbit, the magnitude of the 

 leukocyte response was unaffected by solution dilution until 

 a ratio of 1:5500 was reached; the magnitude of fever was affec- 

 ted by dilutions exceeding 1:3500. 



418. BINKLEY, P., GOEBEL, W. P. and PERLMAN, E. 



Studies on the Plexner group of dysentery bacilli. II. The 

 chemical degradation of the specific antigen of type Z Shigella 

 paradysenterlae ( Plexner ) 



J. Exper. Med. 81:331-34?, 1945 



The specific antigenic complexes of Sh_. paradysenterlae were 

 shown to be phospholipid -acetylated carbohydrate -protein 

 complexes grossly similar to the specific antigens of other 

 gram-negative microorganisms. Dissociation of the antigen 

 complex by acid yields a phospholipid, a carbohydrate and a 

 protein fraction. Only the latter is toxic. On the other hand, 

 alkaline degradation produces the same fractions, with only 

 a carbohydrate possessing toxic qualities. Purther studies 

 on the complex suggest that a purine (or pyrimidine-like) 

 derivative is associated with toxicity. 



419. BONETTI, E. 



Elimination of histldlne and total nitrogen during fever (Tran- 

 slated Title) 



Boll. soc. ital. bid. sper. 20:222-223, 1945 



After Intravenous injection of the pyretamine of Russo, elimin- 

 ation of total nitrogen and of histldlne was accelerated in the 

 early stages of fever; excretion fell below initial levels 

 as temperatures fell. The normal levels of excretion were 

 resumed about 4 hours after fever disappeared. In the 12 hours 

 thereafter some diminution of the output of both total N and 

 histldlne was seen. 



420. BRADLEY, S. E., CHASIS, H., GOLDRING, W, and SMITH, H. W. 



Hemodynamic alterations in normotensive and hypertensive subjects 

 during the pyrogenlc reaction 



