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AGUILAR^ Ro Mo, CORTINA^ M. C„ and VILLAPARD 



Pirogenes y transf uslones de Sangre (Pyrogens and Blood trans- 

 fusion. Preliminary report,) 



Ann. med. Mexico 7sl-6„ 1946 



ALGIRE^ Go H„ 



Effect of a bacterial polysaccharide and of tourniquet shock on 

 peripheral capillary circulation in unanesthetized mice 



Federation Proc, 5:217, 19^6 (Abstract) 



In vivo microscopic studies were made of the effects of a bact- 

 erial polysaccharide from B, prodigiosus and of tourniquet shock 

 on peripheral capillary clreulat'ion frTThe unanesthetized mouse, 

 A transparent chamber introduced into a dorsal skin flap per- 

 mitted daily measurements and photographic studies to be made. 

 In both shock and the reaction to polysaccharide the capillary 

 blood supply decreased to striated muscle and was followed by 

 stasis^ rouleaux formation and occlusiono Capillary dilatation 

 was not seen. After polysaccharide injection^ edema in subcutan- 

 eous tissues was present^ suggesting increased capillary permea- 

 bility. Edema after tourniquet pressure apparently did not cause 

 increased permeability in peripheral tissues, 



ALGIRE^ G, H, 



The vascular reaction of normal and neoplastic tissues to a bac- 

 terial polysaccharide from Bacillus prodigiosus culture filisrate 



Cancer Res, 6s 491., 19^6 (Abstract) 



Changes in the vascular bed of normal striated muscle and of 

 neoplastic tissue were measured through the transparent chamber 

 method. A decrease in the capillary supply to the pannlculus carn- 

 osus layer of striated muscle and to transplanted sarcoma tissue 

 was accompanied by vascular occlusion. Maximal occlusion was 

 seen in three to four hours after injection of B, prodigiosus 

 polysaccharide; recovery of capillary function Followed within l8 

 hours In survivors „ Neither hemorrhage nor necrosis was observed 

 in normal tissues. In sarcoma transplants, occlusion was followed, 

 in three to four hours, by petechial hemorrhage. Necrosis devel- 

 oped. The few tumor cells which survived retained the capacity 

 to obtain a new vascular supply and thereby resume growth. 



