153 



-19^6- 



Physlologlcal studies on tumor-inhibiting agents. II. Effect 

 on rectal temperatures in normal rabbits of the Serratia marces - 

 cens tumor-necrotizing polysaccharide of Shear 



Cancer ReSo 6:410-420, 1946 



Fever of moderate -grade was usually produced by the injection of 

 0.5 micrograms per kg, body weight in the rabbit. Diarrhea 

 generally accompanied the elevation of temperature. The LD50 

 dose for the rabbit exceeds 20 micrograms per kg. but is probably 

 not above 100 micrograms <> For the guinea pig LD50 dosage is from 

 100 to 200 micrograms per kg., and that for the aog appears to 

 be of the same magnitude. The normal mouse tolerates 100 micro- 

 grams per animal, but tolerance is greatly reduced (to I5 micro- 

 grams per mouse) with subcutaneous tumors. The polysaccharide 

 acts through the central nervous system and not the peripheral 

 areas in the animal; this^ is shown by the minute amounts which 

 will produce fever, .-counteraction of fever by antipyretics and 

 extreme vasoconstriction noted after administration. The febrile 

 reaction may be influenced by the environmental temperature. When 

 the spinal cord is cut, the drop in temperature advanees at a 

 rate of over 2° C. per hour, 



441. BEESON, P. B. 



Development of tolerance to typhoid bacterial pyrogen and its 

 abolition by reticuloendothelial blockade 



Proc, Soc, Exper. Biol, & Med, 61:248-250, 1946 



Tolerance develops when daily injection of typhoid pyrogen is 

 continued for a considerable period of time. It is believed 

 that an accelerated rate of disposal of the foreign substance 

 may underlie the phenomenon. The reticuloendothelial system 

 is presumed to be closely connected with this mechanism, since 

 tolerance development is prevented by reticuloendothelial 

 blockade. 



442. BHINDLE, H. and RIGBY, G„ 



The preparation of non-p3rrogenic water and infusion fluids, 

 using activated charcoal 



