15^ . ^ . 



-19^6- 



Qtly. J. Pharm. Pharmacol. 19:302-339* 19^6. See also: Pharm. 

 J. 157:85, 19^6 



Untreated waters from Manchester water mains or from a Cheshire 

 stream were agitated at intervals for 13 minutes with charcoal 

 (0.1 per cent) and filtered through sintered glass. Pyrogenic 

 activity, as shown by production of fever in the rabbit, was 

 much reduced. The average rise in temperature was at least 

 1.50 C. before treatment, and 0.3° C. after. Strongly pol- 

 luted water could not be rendered pyrogen-free if storage 

 preceded treatment. Heavily contaminated pharmaceutical 

 solutions required more than 0.1 per cent charcoal. There 

 was little adsorption of medicaments on charcoal; procaine HCl 

 solution was an exception with adsorption of 27 to 35 per cent. 



443. DILLER, I. C. and SHEAR, M. J. 



Cytological effects of s. marcescens polysaccharide du tumors 



Cancer Res. 6:488, 1946 (Abstract) 



A single injection of the polysaccharide isolated from S. mar - 

 cescens caused striking degenerative changes and damage to 

 cell nuclei in mouse sarcoma 37. Alterations were evident 

 within 2 hours aft^r the injection; cells appear to be most 

 st:g?ongly affected during the division stages. The impact of 

 the polysaccharide was most clearly seen In the period of 

 mitotic activity, and at four hours after administration of 

 the agent no division could be detected. When undamaged cells 

 were seen after 6 hrs., they were in the resting phase. Normal 

 tissues which divide at a rapid rate (intestinal epithelium) 

 were damaged by the polysaccharide. Spontaneous tumors of the 

 rat and mouse and neoplastic tissue from the human patient 

 were examined after polysaccharide therapy. The nuclear 

 changes were similar in all material studied, but the degree and 

 extent varied . 



444. DUNN, T. B. and LEHMANN, S. 



