155 



- 1 9 4 6 - 



Cancer Res, 6:488, 19^6 (Abstract) 



Transplanted epithelial tamors of the mouse appeared to be un- 

 changed on gross examination 24 hours after a single injection 

 (0.1 mg,) of So marcescens polysaccharide. Microscopic examina- 

 tion revealed extensive necrosis in the five types of epithelial 

 neoplasms observed: adenocarcinoma of the small intestine; myo- 

 epithelioma of the salivary gland; pulmonary tumors and two squa- 

 mous cell carcinomas. The effect of bacterial polysaccharides on 

 carcinomas may be overlooked unless microscopic studies are made. 



^^5o GLUCK, R. and WILSO]^, J. L. 



Fever produced by the oral administration of amino acids 



Am, Jo Dis, Child. 71s601-6lO, 1946 



Fever from an undetermined cause appeared in infants ill from ex- 

 cessive dietary Intakes of monosaccharides and casein hydrolysates 

 in sterile solutions. Six well infants had sudden elevations of 

 temperature on the second day of feeding; normal levels were re- 

 sumed within 24 hours. The fever was not associated with dehy- 

 dration nor was it influenced by an antibiotic (sulfadiazine). 

 The work of Reitschel and of Holt is recalled. A specific dynamic 

 action of amino acids and not a pyrogenic effect may be responsi- 

 ble for "oral" fevers, 



446 » FAVORITE, G, 0, and MORGAN, Ho R, 



Therapeutic induction of fever and leucocytosis, using a purified 

 typhoid pyrogen 



J. Lab. Clin. Med, 31:672-676, 1946 



When a purified pyrogenic antigen Isolated from E„ t yphosa is 

 injected intravenously fever, profound leukocytosis, localized 

 pain in the head, back and legs, and occasionally, nausea and 

 vomiting follow. Symptoms disappear, leaving a sense of fatigue 

 and exhaustion. The leukocytosis produced is characterized by 

 the appearance of many granulocytes of the non-filamentous type; 

 glucose, chloride and C02-comblnlng power of the blood vary little 

 from the norm. The leukocytosis was considered the most valuable 

 aspect of pyrogen therapy as shown in the treatment of neurosy- 

 philis. 



447. KOCH, P. K. and OLITZKI, L. 



The action of dysentery toxins on different laboratory animals 

 Exper. Med. & Surg. 4:54-68, 1946 



