162 



- 1 9 4 6 - 



Blood proteose and uric acid, creatinine and creatinine clearance 

 were determined in adult male rabbits after injection 6f a single 

 dose of S. marcescens polysaccharide. All animals bore Brown- 

 Pearce carcinomas at least three weeks old. The range of dosage 

 extended from 5.0 to 300 micrograms per kg. body weight and all 

 animals tolerated 5-D micrograms per kg. At this level, no sig- 

 nificant rise in blood proteose occurred. There was a slight in- 

 crease in blood uric acid with accompanying decrease in glomerular 

 filtration. Hemorrhagic changes in tumor tissue were similar 

 to those which occur spontaneously and were therapeutically 

 unimportant. Larger dosages, in the presence of proliferating 

 tumors, brought peripheral vascular collapse; at the 50 micro- 

 gram per kg. level, tumor hemorrhage, ascites, decrease in renal 

 clearance, collapse and death followed in sequence. 



i^65. WRETLIND, K. A. J. 



About the pyrogen activity of dialyzed casein digest 



Acta Physiol. Scand . 12:385-388, 19^6 (in English) 



Temperatures of rabbits given aminosol (3.3^ solution) by the 

 intravenous route rose an average of 0.41° C. within one hour. 

 The solution was used alone and with glucose additions. In the 

 third hour, the increased temperature still existed to a lesser 

 degree (0.28° C). 



466* ZINOV'EVA, M. T. 



Mineral metabolism. Calcium level in arterial and venous blood 

 in all kinds of fever (Translated Title) 



Byull, Ekspt. Biol. Med. (Leningrad) 21:70-72, 19^6 



Fevers prolonged two days are accompanied by a drop in both the 

 arterial and venous blood calcium content. In fever induced 

 through the injection of metabolism-heightening chemicals (as 

 d initro phenol ) , calcium rises early and falls to normal with the 

 temperature. In pyrexia produced by amine toxins (from putrified 

 meat) the calcium of blood rises only after the reduction of 

 temperature from fever levels. 



