163 



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ALGIRE, G. H., LEGALLAIS, P. Y, and PARK, H. D„ 



Vascular reactions of norffial and malignant tissues in vivo . 

 II. The vascular reactions of normal and neoplastic tissues 

 of mice to a bacterial polysaccharide from Serratia marcescens 

 (Bacillus prodigiosus ) culture 



J. Nat. Cancer Inst. 3:53-62, 19^7 



The polysaccharide fraction P-3 was injected intraperitoneally 

 (0.2 mg. and 0.02 mg.) into mice bearing transparent chambers 

 in dorsal skin flaps. Daily quantitative measurements were made 

 of the vascular bed in normal striated muscle and neoplastic 

 tissues prior to and follov/ing tumor transplantation. The 

 capillary blood supply v^as traced by photographs, as were the 

 changes preceding hemorrhage and necrosis and the pattern of 

 regrov.'th v,'hen it occurred. 



In both normal and neoplastic tissue, a period of vascular stasis 

 preceded hemorrhage. Occlusion of capillaries was observed in 

 both tumor and normal striated muscle tissue; edema was present. 

 Where the tumor host survived, the surviving tumor cells began 

 new growth with capillary proliferation. The mechanism through 

 which hemorrhage and necrosis takes place is closely related 

 to tissue anoxia and capillary damage. 



BARSI, I. 



A new treatment of rheumatoid arthritis 



Brit. M. J. 2:252-253^ 19 '47 



A febrile reaction vjas seen after the first infusion of 300 ml. 

 of blood (from pregnant women) into male and female patients. 

 Improvement of rheumatoid arthritis followed in 6K% of the group; 

 relief from symptoms was spectacular. The possibility that a 

 mild "protein" shock Initiates benefits in this therapy is dis- 

 cussed . 



BECK, L. v., DILLER, I. C, BLAUCH, B. and FISHER, M. 



Reduction in toxicity of Serratia marcescen s polysaccharide to 

 tumor-bearing mice produced by beef adrenal extract (Upjohn) 



Cancer Res. 7:725, 19^7 (Abstract) 



When large doses of Shear's polysaccharide (S. marcescens ) are 

 required to produce hemorrhage and necrosis in extensive or re- 

 sistant tumor transplants in mice, toxicity is the limiting factor, 

 The preparation P-S (National Cancer Institute) was lethal in 



