164 



- 1 9 4 7 - 



500 gamma doses for 64 of 75 mice within 48 hours. All mice 

 bore 7-day transplants of sarcoma 37. A second group, bearing 

 neoplasms of the same age, were given beef adrenal extract prior 

 to administration of P-8 polysaccharide and the same amount 

 (0.25 cc.) at the end of the working day. Of these, 22 In a 

 group of 45 survived 48 hours or longer. The possibility of 

 this difference being the result of chance was estimated to be 

 about 1 in 10,000. A concentrated hog adrenal extract in oil was 

 ineffective in counteracting the lethal effects of P-8 poly- 

 saccharide. 



470. BEESON, P. B. 



Tolerance to bacterial pyrogens. I. Factors influencing its 

 development 



J, Exper. Med. 86:29-38, 1947 



Repeated dally Intravenous injections (7 to 10 days) of pyrogens 

 from E. typhosa , B. prodlglosus and Ps. aeruginosa produces a 

 gradual diminution of febrile response. Tolerance develops and 

 the Increase in body temperature produced is slight and it re- 

 mains constant. Tolerance is lost after a period of rest and 

 pyrogens again produce higher febrile levels, on resumption of 

 injections. No passive transfer of tolerance could be confirmed. 

 Cross tolerance was noted. Antipyretics did not alter the course 

 of development of tolerance. 



Amldopyrlne, administered through a stomach tube 1 hr. before 

 injection of typhoid vaccine, prevented febrile response. Cab- 

 inet fever therapy did not reduce responsiveness to pyrogens. 



471. BEESON, P. B. 



Tolerance to bacterial pyrogens. II. Role of the reticuloendo- 

 thelial system 



J. Exper. Med. 86:39-44, I947 



Tolerance to pyrogens in rabbits may be the result of stimula- 

 tion of the reticuloendothelial system. After tolerance was 

 established, febrile response could be heightened through blockade 

 of the reticuloendothelial system. Tolerance develops, according 

 to the hypothesis presented, when, ability to remove pyrogens 

 (or other bacterial toxins) from the blood is enhanced through 

 awakening of the defense mechanism. Protection Is thus given 

 against tissue injury. 



472. BEESON, P. B. 



