166 



-19^7- 



purpuric meningococcemla. Bilateral renal necrosis, found 

 after Injection of living organisms, was believed to be the 

 product of vasospasm and the thrombosis it engendered. 



476. BOQUET, P., DELAUNEY, A., LEHOULT, Y, and LEBRUN, J. 



Action d'un extrait du bacille typhlque sur la pression arterielle 

 du lapin (Action of an extract of Bacillus typhosa on the 

 arterial pressure of the rabbit) 



Compt. rend, Soc . biol, 141:269-271, 19^7 



Marked, rapid and sustained peripheral vasoconstriction followed 

 injection of B. typhosa endotoxin in the rabbit. Two to I6 mg. 

 of the toxic substance were injected by subcutaneous, intra- 

 peritoneal or intravenous routes. The carotid pressure remained 

 constant during the toxic period; in extremes, a reduction occurs, 

 as would be expected. 



477. BOQUET, P., DELAUNAY, A,, LEHOULT, Y. and LEBRUN, J. 



Observation direc^e des reactions vasculalres cutanees chez le 

 lapin soumis a I'epreuve d ' une endotoxine typhique (Direct 

 observations of the cutaneous vascular reactions in the rabbit 

 subjected to typhus endotoxin) 



Compt. rend, Acad. Sci, 225:1193-1194, 1947 



The reactions of cutaneous vessels in the ears of rabbits were 

 studied by means of window-flaps and microscopic examinations. 

 Contraction of a severe degree occurs 5 to 15 minutes after 

 intravenous or intraperitoneal injection of 6 to 8 mg. of a 

 B. typhosa polysaccharide-lipid-polypeptide antigen; the cycle 

 of alternating dilatation and contraction which follows is con- 

 fined to arterioles alone o Removal of the upper cervical 

 ganglion did not alter the response. The initial response to 

 purified B. typhosa antigen is believed to be independent of 

 local sympathetic innervation and to resemble similar reactions 

 observable in anaphylactic and traumatic shock. Leucopenia 

 and inhibition of diapedesls accompany this manifestation of 

 Intoxication, 



47a BRADLEY, S. E. and CONAN, No J. 



Estimated hepatic blood flow and bromsulfalein extraction in 

 normal man during the pyrogenic reaction. 



J. Clin, Invest. 26:1175, 1947 (Abstract) 



The cardiac output and renal blood flow are increased after 



