16? 



19^7- 



pyrogen administration even v;hen fever is prevented by anti- 

 pyretic drugs. Hepatic circulation in normal human subjects 

 before, and after, intravenous injections of typhoid vaccine 

 was traced through bromsulfalein clearance and hepatic 

 venous cateterization. The blood flow in the liver increased 

 in all subjects; to 300 per cent increase was noted in one 

 indi\/idual. Despite hyperemia and increased bromosulfalein 

 loading, the latter was removed from blood at a rate 50^ below 

 normal levels. Hepatic venous pressure rose occasionally as 

 hyperemia developed in the liver. 



^-'.7 1, BRAGDON, J, H, 



The hepatitis of hyperthermia 



New England J. Med, 237:765-769, 1947 



Liver damage may be seen after fever is induced by physical or 

 biological methods. Hepatitis, believed to be of virus origin 

 may be activated through increased body temperatures. The 

 critical temperatures above which liver cells are irreversibly 

 changed are probably varied, but are believed to be not far 

 above those encountered frequently. Anoxia, or the destruction 

 of functioning enzyme systems, may underlie liver cell necrosis; 

 the same factors are destructive to certain central nervous 

 system cellular components. 



nSi:'. BUENO, P. 



Reticuloendothelial cells reacting to toxic antigens and to 

 infection 



Archo Path. ^4:635-638, igii-J 



Nuclear tumefactiou and disintegration in the undifferentiated 

 mesenchymal cells, in germinal elements of lymphatic tissues 

 and lymph nodes, and the Kupffer cells of the liver of the guinea 

 pig followed subcutaneous or intracardiac injection of the anti- 

 gens of p aratynhoid A., brucellosis, anthrax, tetanus and 

 diphtheria, organisms, ...--. ... 



Close relationships exist between sites of antigen activity and 

 those concerned with antibody formation, 



v.e. . CHAMBKRS, W, W. and WINDLE, W. F, 



Site of action of a bacterial pyrogen in cats with central 

 nervous system lesions 



