168 



-1-9 4 7- 



Pederatlon Proc. 6:89, 19^7 (Abstract) 



In the normal cat Injection of a purified pyrogenic extract 

 obtained from Fseudomonas aeruginosa (PYROMEN) produced pilo- 

 erection, chills and fever"! Only fever occurred when the pyro- 

 gen was administered to cats with chronic hypothalamic lesions 

 and no response was registered in the chronic spinal animal. 

 The last-named show poor adjustment to environmental temperature 

 changes. 



4.82<. COLLIER, H. 0, J, and PARIS, S. K. 



_, The decline of pyrogenic activity of intravenous solutions during 

 storage 



Quart. J. Pharm. Pharmacol. 20:376-380, 19^7 



It has been reported that strongly pyrogenic solutions may lose 

 their activity during storage. To test the validity of this 

 theory, solutions of ten compounds commonly used for intravenous 

 therapy were stored at reduced pressures (508-635 mm. Hg.) and 

 tested for pyrogen content at intervals. Solutions included 

 saline, dextrose M/6 sodium lactate. Darrow's solution, Hart- 

 mann's and sodium sulphate solutions. 



The average span of pyrogenic activity was 92 days or less; in 

 one instance^ pyrogens were present after 110 days storage. 

 Temperature and light were relatively unimportant factors in the 

 storage life of pyrogens; initial concentration of pyrogens in 

 solution was less significant than the chemical nature of the 

 pyrogen under consideration and the presence of stabilizing 

 substances. Two solutions of the same type may contain pyrogens 

 widely dissimilar. The rate of loss of pyrogenicity varied 

 widely. In general, dilute solutions were less stable for 

 pyrogen retention, but it was noted that such substances can 

 exist in solid materials, eg. dextrose. It was also noted that 

 the febrile activity of pyrogens wanes after long storage. 



'i^BS* CONDINI, P. 



Amora sulla bactererterapia dei tumori (Bacterlotherapy of tumors) 

 Terapia (Milan^ 32:69-70, 19^7 



'4tS4. CREECH, H. J., HAMILTON, M, A., DILLER, I. 6,, NISHIMURA, E. T. 

 and SHEAR, H. J. 



Comparative studies of the immunological, toxic and tumor-necro- 

 tizing properties of S. marcescens polysaccharides 



