170 



-19^7- 



In mice was not Inhibited by simultaneous administration of 

 adrenal cortical extract. The necrotizing effect was delayed 

 with maximal effects appearing in 24 hours. Chemical as well 

 as structural changes are suggested by the appearance of the 

 cytoplasm of cells and their staining characteristics. Cellular 

 changes in adrenals of the host follow administration of either 

 substance alone; damage appears to be prevented by simultaneous 

 injection. 



48?. EDSALL, G. and WETTERLOW, L. H, 



Missed contaminations in biologic products: The role of 

 cryophlle bacteria 



J. Bact, 54:31-32, 1947 



Bacterial species which thrive below the incubation temperature 

 ranges produce pyrogens; refrigerated serums^when once contami- 

 nated, are fertile sources of such pyrogenlc substances. Gram- 

 negative organisms which grow only at lower temperature ranges 

 have been isolated; they resemble Pseudomonas and grow most 

 actively at 20 to 25 degrees C. but will multiply at degrees. 

 Tests for pyrogens should be made at room temperature as well 

 as at 35 to 37°C. 



488. PELTON, L. D., PRESCOTT, B., KAUFMAN, G, and OHINGER, B. 



Studies on immunizing substances in pneumococci. XIV. The dis- 

 tribution of specific polysaccharide in mouse tissues after 

 injection of a "paralyzing" dose 



Federation Proc. 6 (Pt. 2) 427, 1947 (Abstract) 



In the mouse a large dose of the antigenic polysaccharide of 

 pneumococci "paralyzes" the immunologic mechanism for about 15 

 months; the phenomenon is type-specific. The concentration of 

 the antigen in the tissues was traced and comparisons made of 

 hlstochemical preparations from normal animals. In order of 

 decreasing precipitin titer the polysaccharide was found in 

 these tissues: liver, spleen, kidney, skin, bone marrow. In 

 some instances, it could be demonstrated in muscle and lung 

 tissues and in urine and the intestines. It was present after 

 15 months in the liver but had decreased or was absent in other 

 tissues. Mice Injected with a paralyzing dose of whole cell 

 vaccine showed similar distributions of polysaccharide. 



