172 



-19^7- 



Multlplication of the mumps virus in the chick embryo can be 

 inhibited by the capsular polysaccharide of Friedlander 's 

 bacillus , type B. After adsorption of the polysaccharide 

 chick erythrocytes do not adsorb the virus. 



493. HARTLEY, P. 



The decline of pyrogenic activity in intravenous solutions 

 during storage 



Quart. J. Pharm. Pharmacol. 20:444, 194? 



Wide variations in stability between different types of solu- 

 tions must be considered in reckoning the rate of disappearance 

 of pyrogens in stored solutions. Rapid disappearance of pyro- 

 gens may be seen in one and long continuation of pyretic acti- 

 vity in another. The presence of pyrogenic activity can be 

 demonstrated after three years' storage. 



494' HOLLOMAN, A. L. 



Reactions of patients and of tumors to injections. of Serratia 

 marcescens polysaccharide in eight cases of malignant disease 



Approaches to Tumor Therapy , Araer, Assn. for the Advancement of 

 Science, Washington, D. C. XI. pp. 273-276 



Four patients with fibrosarcoma, two with Hodgkin's disease, 

 one with malignant melanoma and some with chondrosarcoma were 

 treated with the polysaccharide of S^ marcescens . The initial 

 dose was O.OO5 mg.; this was increased later to 0.04 mg. in a 

 single dose. Reactions were severe and resembled those of 

 shock, although anti-shock therapy was Ineffective in treatment. 

 Elevation of the lower half of the body, and continuous intra- 

 venous drip of a solution of 5^ glucose in saline, containing 

 1 mg. of thiamine and a low concentration of epinephrine were 

 employed. The highest temperature elevation recorded was 10S.4°F, 

 A short intense rise in blood pressure was succeeded by hypoten-.". 

 sion. 



495* HORSFALL, P. L,, JR. 



The modifying effects of certain substances of bacterial origin 

 on the course of Infection with pneumonia virus of mice (PVM) 



V. 



J. Exper. Med. 85:623-646, I947 



Since it has been demonstrated that Infection subsequent to 

 Inoculation with pneumonia virus could be modified in mice by 

 injections of streptococcus MG , the effect of other bacterial 

 species was determined after Intranasal inoculations with PVM. 

 Both living and dead bacteria in various concentrations and 



