173 



19^7- 



bacterlal polysaccharides were employed. In addition, non- 

 bacterial polysaccharides were injected. Varied time intervals 

 between inoculations were observed. Streptococcus MG , S. sali - 

 varius , type II and Group A hemolytic strentococcus were in- 

 jected during the test periods. A second pneumococcus organism, 

 E. coll and H. influenzae , type B., were included in the group. 

 Virus titration end points and hemagglutination titers were 

 determined in the infected lungs as well as the frequency and 

 degree of pulmonary consolidation o 



Both bacterial and non-bacterial substances modified the 

 course of PVM Infection, but were inactive when administered 

 by other than the nasal route. They appeared to inhibit virus 

 multiplication. Competition may exist between these active 

 substances and PVM for some intracellular system required for 

 multiplication of the virus. Chemical blockade of virus re- 

 ceptors in the cells of the respiratory tract did not appear 

 to be involved in the mechanism of inhibltiono The evidence, 

 still unconfirmed, would indicate that the active component 

 may be a purified polysaccharide, 



496. JAGER, B. V. and NICKERSON, M. 



The altered response of human beings to the intramuscular ad- 

 ministration of typhoid vaccine during massive salicylate therapy. 



Am, J, Med, 3:^08-422, 19^7 



The effects of injection of typhoid vaccine in a control group 

 of healthy adults and in patients suffering from arteriosclerotic 

 heart disease, acute rheumatic fever and from multiple sclerosis 

 were contrasted vilth those observed in 14 patients receiving 

 massive salicylate therapy, A number of Individuals in both 

 groups had been previously immunized against typhoid. Salicy- 

 lates as medication had been administered for periods ranging 

 from 7 to 132 days before typhoid injections, and were continued 

 for 16 to 70 days after. 



While the control group exhibited typical reactions to typhoid 

 vaccine - development of H and antibodies, transient leuko- 

 cytosis, lymphopenia, a rise in the red cell sedimentation rate 

 and plasma fibrinogen levels and Increases in gamma globulin - 

 the patients treated with salicylates had only slight changes 

 or none. The systemic and local reactions noted in individuals 

 previously Immune to typhoid were absent during massive sali- 

 cylate therapy. Antibody production may be prevented through 

 the action of salicylates by a reduction in toxicity of antigenic 

 proteins or through selective liver damage which Inhibited pro- 

 duction of precursors c A direct action on lymphocytic antibody 

 production may be the result of adrenal and pituitary stimula- 

 tion or there may be rapid destruction of typhoid toxins in the 

 circulation. 



