- 1 9 4 7 - 



4^97. KTJN, E. 



Effect of meningococcal endotoxin on histamine content of blood 

 and tissues of rabbits 



Proc. Soc, Exp o Biol. Med, 66:197-201, 1947 



Intravenous injection of meningococcal endotoxin reduces 

 blood histamine and Increases that of liver and muscle. Hista- 

 mine levels in the blood could not be sustained by simultaneous 

 administration of endotoxin and histamine; the latter procedure 

 appeared to shorten the survival time of test animals. 



:498. McCONNELL, J. R.^ HALLETT, S. P. and SHEAR, M. J. 



Effect on sarcoma 37 in tissue culture of two tumor-necrotizlng 

 agents 



Cancer ReSc 7s7l6^ I947 (Abstract) 



Hanging drop cultures of sarcoma 37 grown for I8 hours were 

 treated directly with concentrations of emetine hydrochloride 

 ranging from 10 mg. per cc„ to 0=00001 rag. The cells rapidly 

 disintegrated, nuclei shriveled and became pyknotic. The rate 

 of destruction was proportional to emetine concentration and 

 toxicity appears to reside in a rapid surface reducing effect. 

 Similar concentrations of S. marcescens polysaccharide produced 

 no necrotlaslng effect in vTFro. The method is informative but 

 does not appear to be as reliable as a screening procedure as 

 in vivo tests, 



499. MONDOLPOp Ho and HOUNIE, E, 



Sobre el orlgen del plrogeno bacterlano (On the origin of 

 bacterial pyrogens) 



Dla Med, 10:1724-1725, I947 



In a review of the factors concerned with pyrogen production, 

 the role of culture medium in increasing pyrogenlclty of super- 

 natant fluids is described. Blood serum Increases the pyrogenl- 

 clty of E. coll cultures. 



500. MORGAN, H. R. and, BENNETT, G, A. 



Intra -articular changes Induced in rabbits by Injection of typhoid 

 somatic antigen 



Arch, Path. 44s609-620, 1947 



The toxic somatic antigen of S. typhosa was injected directly 

 into the sub-patellar Joint of the rabbit in dosages ranging from 

 0,25 mgo to 0,5 rag. and the injections were continued at inter- 

 vals of 3 to 7 days for varying periods of time. Concomitant in- 

 jections Intradermally were employed as conditioning procedures 

 preparatory for the Shwartzman reaction and were followed by 



