lib 



- 1 9 ^t 7 - 



provocative injections l8 to 24 hours later. Tissues were ex- 

 amined both iiiacroscopically and microscopically, 



Repeated intra -articular injection of the antigen produced acute 

 arthritis v^hich progressed to a chronic state. Synovial tissue 

 hypertrophy, surface "lipping" and subsynovial lymphoid accumu- 

 lations were seen. The dermal reaction passed through a self- 

 limiting course. Vascular thrombi were extensive throughout 

 heart, lungs and liver. 



NASr^TB, P. A, 



The decline of pyrogenic activity in Intravenous solutions during 

 storage 



Quart. J. Pharm. Pharmacol, 20:'i-45, 19^7 



In the discussion during the symposium, Nasmyth noted that the 

 work of Collier and Paris^ just reported, had shown that a vjide 

 range of temperatures might be seen in the normal rabbit. In 

 the seven employed by these investigators, the differences ex- 

 tended to 500^ and the lower of the temperatures recorded in 

 these rabbits was TA'ell within normal limits for the species. 



OAKEY, R, 



Reactions of patients to injection of Serratia marcescens poly- 

 saccharide in nine further cases of malignant disease 



Approaches to tumor therapy , 



American Association for the Advancement of Science, 1947* pp. 

 277-27-3 



Serrati a marcescens polysaccharide may be given to patients re- 

 peatedly with the necessary safeguards against extreme toxic and 

 shock states. No tumor vjas completely destroyed when 0.03 to 2.0 

 mg, of polysaccharide was given in 1 to 14 injections to members 

 of a group of 9 patients bearing tumors of varied types; changes 

 in the f^ize and consistency of most of them could be seen. The 

 systemic reactions were similar to those noted with other pyro- 

 genic substances; the most alarming feature was the fall in 

 blood pressure with its threat of complete peripheral circula- 

 tory collapse, 



OGHOA, A, G. and PIGUEROA, E, S, 



Los Polisacaridos de Sporotrichum schenckii (Polysaccharides 

 of Sporotrichum schenckii) 



