17^ 



-19^7- 



Por multiple sclerosis^ pyretotherapy, vaccines, antlmyelotic 

 substances, coagulation inhibitors, vasodilators and radio- 

 active materials were ineffective. Some results were seen in a 

 few patients after antihistamine administration , The brain 

 tissue extract of V, Muralt is said to activate nerve regenera- 

 tion; a tentative trial of this substance is suggested by the 

 author. 



ROTENHEIM, C. A., SATKE^ H. A. and LIMAYE, M. V. 



Uber Pyrogene (On pyrogens) 



Pharm, Acta Helveto 22:673-678, 19^7 



A review of pyrogens, from the standpoint of the interest of 

 pharmacist and manufacturer, with methods for eliminating such 

 substances from solutions. 



SACK, T. and SELIGMN, A. M. 



Some effects of iodinated bacterial polysaccharide on patients 

 with malignant tumors 



Cancer Res o 7:715* 19^7 (Abst.) 



When iodinated polysaccharide from So marcescens was administered 

 intravenously to seven patients with metastatic carcinoma, the 

 effects of massive dosage could be observed, since from 2 to 

 3000 gammas were administered as individual doses. Post-injection 

 reactions followed a common pattern, namely, chill, a temperature 

 increase sustained for one or more hours and a gradual fall to 

 normal levels within 12 to 30 hours after injection. The blood 

 pressure rose during the chill, fell when temperature reached 

 maximal levels, with a hypotensive period occurring 8 to 15 hours 

 after injection. In four Instances antishock therapy was re- 

 quired. Asthmatic symptoms, albuminuria and mild congestive 

 heart failure appeared » However, the reactions did not differ 

 markedly from those which occur after administration of the un- 

 treated polysaccharide. Post-injection exhaustion appeared to 

 be prevented or greatly reduced by adrenal cortical extract, 

 given in combination with the iodinated polysaccharide » 



SMITH, W„ E. and PENNELL, R. Be 



Reducing the pyrogeniclty of concentrated protein solutions 



J, Bact. 5^:715-718, 19^7 



A method is described for elimination of pyrogens from concen- 

 trated protein solutions, such as serum, plasma and hemoglobin. 



