178 



-19^7- 



This is accomplished through the use .of a new type of Setlz 

 pad, special filters and an ion exchange agent "decalso". 

 "Pyrogen removal is a function of the degree of pyrogeniclty 

 and the concentration of the protein solution and the proper 

 relationship of the amount of 'decalso' and filter pad area to 

 these variables." 



510. STUTTGEN, G. 



Die Beeinflussung des cholinesterase im Serum des menschlichen 

 Blutes durch pyrifer und Uo V. Bestrahlung, besonders im hin- 

 blick auf die Therapie einzelner Dermat^sen (Regulation of 

 cholinesterase in human blood serum by means of pyrifer and 

 U. V. light rays, particularly in view of therapy of certain 

 dermatoses) 



Klin. Wchnschr, 24:758-759> 19^7 



It has been postulated that the bacterial product, pyrifer, 

 regulates the Equilibrium maintained between the vagotonic and 

 syrapathotonic systems. In testing this theory, its effect 

 on cholinesterase was ascertained. It was noted that, with 

 increased cholinesterase activity, ultra violet light rays 

 produced erythemic skin changes, 



511. WEGER, P. 



tJber rein dargestellte hochwirksame Pieberstoffe (Highly potent 

 pure pyrogens ) 



Naturwissenschaften 34:59-60, 19^7 



The effects of pyrogens from Eo typhus , E. coll., proteus , 

 pyocyanus and abortus equi organisms were observed in the rabbit, 

 mouse, horse and in man, A response could be elicited in the 

 rabbit through the administration of 0.25 micrograms, but 

 higher doses gave a higher temperature level. During this 

 period animals appear quite normal and maintain their weights. 

 Tolerance does not appear on repeated daily injections, while, 

 in human beings* increased doses must be administered in order 

 to achieve the same responses o 



Chemical analyses of the pyrogens used are reported. 



