179 

 -19^3- 

 512. ALBSRTY, R. A. and HEIDELBERGER , M. 



Fractionation and physical-chemical studies of a comtnercial 

 preparation of the specific polysaccharide of Type I pneumococ- 

 ous' 



J. Am. Chem, Soc , 70:211-213, 1943 



A colloidal electrolyte was separated from Type I pneumococcus. 

 Electrochemical and solubility characteristics resembled those 

 of the proteins." The crude preparation showed an isoelectric 

 point at pH 2.3, After fractionation with isopropyl alcohol, 

 electrophoresis gave an isoelectric point for one component, 

 that of nucleic acid, slightly below this figure (2,0). 



513- ALEXANDER, L., LOMAN, J., LESSES, M, F. and GREEN, I. 



Blood and plasma transfusions in multiple sclerosis 



Multiple Sclerosis and the Demyelinating Diseases . Baltimore, 

 The Williams arJ WlTkIns~Co., l9$0. Chapter 13. 



The high incidence of pyrogenic reactions in patients with multi- 

 ple sclerosis is in contrast with those reported in the litera- 

 ture on transfusion reactions. 



Fifty patients in a group of 111 with multiple sclerosis were 

 selected for study. Whole blood and plasma transfusions were 

 given on the theory that, if it be a virus disease, passive 

 Immunity m.ight be conferred through active immunity existing in 

 healthy donors. Saline infusions and immune globulin injections 

 were utilized in an effort to obtain information on fractions 

 of blood which might be therapeutically useful. Reactions oc- 

 curred in 27:^ of the 293 transfusions given or in 50^ of the pat- 

 ients. There were no hemolytic reactions. There were 30 pyro- 

 genic reactions involving iBfo of the patients. Allergic symptoms 

 appeared after transfusion in lk%. lOfo of these were seen 

 during the first transfusion. Both allergic and neural symptoms 

 were often present in combination , Fever > temporary paralysis 

 or spasticity, diplopia and "blindness" were seen. In the group 

 of 23 patients who were benefited by transfusion, 60fo had reac- 

 tions. Of these, 26fo were allergic reactions. Among the 

 patients who did not improve after transfusion, 30^ had allergic 

 reactions. Clinically significant improvement was seen in 3V 

 of all patients treated; 6^ had incomplete remissions, three 

 complete remission. Improvement vjas seen in but one patient 

 after injection of immune globulin. 



514. BAYER, 0. and HORSTER, J. A. 



Morphologische Veranderung an Plasmocytomzellen unter Pyrifer- 

 wirkung (Morphologic alteration in plasma cells mider pyrifer 



