183 



-19^3- 



522. DILLER, I. C., BLAUCH, B. and BECK, L, V. 



Histological changes In adrenal glands of turaor-bearing mice 

 injected with Serratla rnarcescens polysaccharide alone and in 

 combination with adrenal cortical extract 



Cancer Res. 8:591-605, 19^8 



Young albino mice bearing 7 "day-old implants of sarcoma 37 

 were injected with either 0«02 mg. P-3 polysaccharide intra- 

 peritoneally ot O.5 cc , of adrenal cortical extract (Upjohn) 

 by the same route but in divided doses or the tv;o substances 

 in combination. Similar experiments were carried out with mice 

 bearing methylcolanthrene induced tumors and also with litter 

 mates. Both survival studies, tumor growth measurements and 

 histologic examinations of tumor and adrenal tissues followed. 



Either the polysaccharide or the adrenal cortical extract caused 

 tumor hemorrhage and necrosis, and similar effects on the adrenal 

 glands were noted. The adrenal medulla showed more extensive 

 necrotic changes than did the cortex. In combination, poly- 

 sacchaEide and adrenal cortical extract delayed tumor necrosis and 

 produced minimal glandular changes. In healthy mice or tumor 

 bearing mice where the growth Is still in the primary stages, no 

 tumor necrosis and little adrenal damage followed the adminis- 

 tration of these agents 



^ O c 



523. FARR, R. S., LEQUIRE, V. S„, SCHORK, P. K. and GAYHART, C. H. 



The augmentation of the pyrogenic and leukocytic effects of typhoid 

 vaccine by homologous plasma in the rabbit 



Project NMOO7039. Report No. 17, Kaval Medical Res. Inst. 19^8 



This article is reviewred in detail in: Proc. Soc . Expero Biol. 

 & Med. 75:661-666, 1950 



524. FRONTALI, N. and TOOCHI, G. 



Gil inhibitori enzlmaticl nel process© febbrlle; (Enzymatic 

 inhibitors and the febrile process) 



Boll. Soc. ital. biol. sper. 24:245-2^7, 1948 



"Piretamlna" was administered by various routes and the effect 

 of chemical inhibitors assessed, 



525. GINSBERG, H. S., GOEBEL, W, F. and HORSFALL, P. L., JR. 



