184 



- 1 9 4 8 - 



The inhibitory effect of polysaccharide on mumps virus multi- 

 plication 



J. Exper. Med, 87:385-410, 1948 



The viruses of mumps, influenza A and B and Newcastle disease 

 were cultivated in allantoic fluid and Inoculated into fertile 

 seven-to-eleven-day-old eggs. The inhibitory properties of 

 the capsular polysaccharides of Fried lander's bacillus , types 

 A, Bp and C, and streptococcus MG polysaccharide were tested, 

 as were those of levari and dextran, blood group substance A, 

 apple pectin and commercial corn starch. Hemagglutination was 

 used as a measure of mumps virus concentration. It was found 

 that the polysaccharides from type specific Friedlander bacilli 

 inhibit the multiplication of mumps virus in the allantoic 

 sac of the chick embryo c Concentrations as low as five gammas 

 were effective. This polysaccharide had no effect on other 

 viruses used. in the studies, and no other polysaccharide inhibi- 

 ted mumps virus. The mechanism involved may be one of blockade 

 of the metabolism of host cells and not one Influencing the 

 virus or its infectivity 



526. GINSBERG, H. S., GOEBEL, W. P, and HORSFALL, P. L,, JR. 



The effect of polysaccharides on the reaction between erythrocytes 

 and viruses, with particular reference to mumps virus 



J. Exper. Med. 87:411-424, 1948 



In an effort to determine whether or not a single mechanism is 

 involved in the inhibition of hemagglutination and multiplication 

 ° /I'^J^"^®^ ^ ^^^ polysaccharides of Friedlander bacilli A, B, 

 and C, or of other non-bacterial polysaccharides, the viruses 

 oi mumps. Influenza A, B, and Newcastle disease or PVM were ti- 

 trated against chicken, human group and mouse erythrocytes. 

 Polysaccharides active as inhibitors do not block adsorption 

 Of the virus by erythrocytes nor by cells of the living allantoic 

 memDrane in all instances o There is no correlation between 

 effects of polysaccharides on hemagglutination by viruses and 

 tneir inhibition of virus multiplication. Wide variation is 

 shown between in vitro and in vivo inhibiting activity of 

 polysaccharides. 



527. HALL, V. E., FIELD, J. and GRANT, R. 



The metabolic activity of the central nervous system as it affects 

 the thermostatic behavior of the body. 



Memorandum Report, MCREXD-686-113D, UoS, Air Force Materiel 

 command, 194o 



