1S7 

 - 1 9 4 8 - 

 KUN, E. 



Effect of bacterial endotoxins on glycogen synthesis 

 Procc Soc. Exper. Biol. & Med. 68:496-498, 1948 



The influence of endotoxins from Salmonella and meningococcal 

 organisms upon the synthesis, in vitro and in vivo , or glycogen 

 was studied. In the rat diaphragm and rabbit liver slices 

 there was inhibition of glycogenesis from pyruvate and glucose; 

 insulin diminished this inhibition in vitro in the rat diaphragm, 

 In vivo toxins completely prevented glycogenesis in the liver 

 oT the rat. 



535. KUN, E. 



Inhibition of the phosphorylation of glucose by meningococcal 

 endotoxin 



J. Biol. Chem. 174:761-762, 1948 



Since the addition of Zn-free insulin to meningococcal endotoxin 

 prevents the inhibition of glucose utilizarion^'in rat muscle 

 extracts in vitro , it is believed that meningococcal endotoxin 

 prevents phosphorylation of glucose through a reduction of 

 hexokinase activity. " , . oThe disturbances of the carbohydrate 

 metabolism in meningococcal toxemic rabbits and meningococcic 

 meningotis in humans,., may be explained by a direct effect of 

 meningococcal endotoxin on ensyraatic reactions in the host.,," 



536. KUN, E., and MILLER, C. P, 



Effect of bacterial endotoxins on carbohydrate metabolism 

 of rabbits 



Proc. Soc. Exper o Biol. & Med, 67:221, 1948 



The injection of lethal doses of sterile, unpurified meningo- 

 coccal and Salmonella endotoxins in the rabbit, increased blood 

 glucose, lactic acid and inorganic phosphorus.. Liver glycogen 

 decreased while lactic acid content of tissues increased; pyruvic 

 acid in blood and tissues was much reduced. Succinic -dehydro- 

 genase activity in both muscle and liver was inhibited; cyto- 

 chrome oxidase activity v/as not affected. A state of tissue 

 anoxia may exist vjith corresponding interference with carbo- 

 hydrate metabolism. 



