189 



-19 4^ 



u — 



J. Clin. Invest. 27:706-709, 1948 



Seven patients, two with gonorrhea, two with asymptomatic sero- 

 logic syphilis and three without Infections, received either 

 the somatic antigen of S. typhosa , that of S. schottmullerl or 

 Sh. d ysenterlae . Tolerance to the toxic effects of the antigens 

 Be"vel8ped after repeated Injections. Subsequent Injections did 

 not produce hyperpyrexia and other symptoms, and cross-tolerance 

 developed between the heterologous antigens. However, specific 

 "0" agglutinins were demonstrable only for Immunologically re- 

 lated antigens. 



540. MORGAN, H. R. 



Tolerance to the toxic action of somatic antigens of enteric 

 bacteria 



J. Immunol. 59:129-134, 1948 



Rabbits developed tolerance to the pyrogenlc effect of the so- 

 matic antigens of S. typhosa , S. schottmullerl and Sh. dysen - 

 terlae within three to four days following initial intravenous 

 injections. Such tolerance was not specific for antigenic 

 structure and appears to bear little relationship to the pre- 

 sence of specific circulating antibody. After a rest period, 

 the teslstant state disappears at a time when the level of cir- 

 culating antibody still remains specifically elevated. Animals 

 develop specific antibodies without comparable decreased in 

 febrile response to pyrogenlc antigen, and the preparation from 

 Sh. dysenterlae which is but feebly antigenic induces an active 

 state of tolerance. 



541. PINGERT, P. P, and PERRY, C. W. 



U, S. Patent 2,432,970, 1948 



A method for reducing the pyrogen contents of parenteral solutions 

 sensitive to temperature changes and to usual acid and alkaline 

 treatments is described, 



542. RABINER, A. M., ROSENBERG, M. and FRIEDMAN, H. 

 Neuronitis and neuronapathy 



Ann. Int. Med. 29:432-444, 1948 



For 6 of a group of 7 patients presenting the classic symptoms 

 of acute infectious neuronitis or neuronapathy, benefit was 



