- 1 9 4 8 - 



seen after typhoid vaccine therapy. Relief of pain was the 

 most dramatic feature of this treatment. Acute inflammation of 

 the peripheral nerves, nerve roots, brain stem and cord sub- 

 sided more slowly, and the recovery of motor power lagged behind 

 other improvements. In two patients there was an immediate 

 return of sensation after the first injection of vaccine; in 

 others, a considerable delay was observed. In the areas in- 

 volved, regional hyperesthesia and hyperalgesia were noted. 

 The excellent responses to vaccine therapy which occurred with- 

 out noteworthy temperature elevations would appear to challenge 

 the current belief that the beneficial effects of vaccino- 

 therapy depend on the creation of lethal environmental condi- 

 tions for infecting organisms. 



543. RAUSS, K. 



A dysenterla vedoltas kerdese (The problem of immunization 

 against dysentery) 



Nepegeszsegugy, 29:449-454, 1948 



Trichloracetic acid extracts of S. dysenterlae protect mice 

 against infection while type-specific activity is found in 

 vaccines prepared from the same organism. It is believed that the 

 toxic substance and the protective factor are identical. 



544* SACK, T. and SELIGMAN, A. M, 



Chemical alteration of polysaccharide from Serratla marcescens . 

 II. Effects of lodopolysaccharide in patients with malignant 

 tumors 



J. Nat. Cancer Inst. 9:19-34, 1948 



Intravenous injections of lodopolysaccharide, in dosages ranging 

 from 2 to 3*000 gammas, were administered to seven patients with 

 inoperable or recurrent Roentgen-resistant malignant tumors. The 

 polysaccharide was given over varying periods ranging from 1 to 

 d4 days, or 1 to 9 injections. The toxic reactions which fol- 

 lowed resembled those observed after the administration of un- 

 modified polysaccharide and consisted of a prodromal period, a 

 chill 15 to 45 minutes after injection, a period df flush and 

 maximal temperature and progressive hypotension and defervescence. 

 Tolerance to lodopolysaccharide developed rapidly. Cross resis- 

 tance to the effects of unmodified polysaccharide appeared. No 

 -olinidai ev-ldenee of tumor destruction could be found. 



