193 



-19^8- 



patients became free of retinal hemorrhages and, of l6 patients 

 with congestive heart failure, five were relieved during therapy; 

 electrocardiograms became normal in seven, and heart size de- 

 creased, for the entire group, from plus 1% to plus 5^ during 

 treatment. Tolerance to pyrogens appeared in five to nineteen 

 weeks when arterial pressures rose. However, the malignant 

 syndrome did not, in the majority of patients, reappear. 



Remissions for periods of 24 to 30 months, on an average, were 

 obtained by consistent treatment. Bacterial pyrogens are effec- 

 tive in the absence of severe renal damage. 



550. WAKIM, K. G., KRUSEN, P, H. and ELKINS, E, C, 



Effect of artificially induced fever on circulation in arthritic 

 patients 



Arch. Phys. Med. 29:274-284, 1948 



In a discussion of fever production through the use of passive 

 (physical) agents and active substances (colloids, bacterial 

 proteins, living parasites), it is noted that prodromal and 

 chill phases are absent in the former. Both increase leukocyte 

 formation and accelerate cardiac output, blood flow and the size 

 of capillaries. There is an increase in metabolic catabolisra. 



51. WELL9 J. A. and RALL, D, Po 



Mechanism of pyrogen-lnduced fever 



Proc. Soc. Exper. Biol, & Med. 68:421-424, 19^8 



pyrogen (PYROMEN) will induce fever under conditions where 

 increased heat production from muscular activity is impossible. 

 Under such conditions, the mechanism of the pyrogenic reaction 

 is one of rapid reduction of heat losses. 



