197 



-19^9- 



Technlques for production of nonpyrogenic solutions are outlined. 

 Freshly distilled water should be used In preparing solutions. 

 Adsorption of pyrogens by activated charcoal or asbestos is 

 possible. Inactlvatlon with 0.01 N/HCl with subsequent neutra- 

 lization of the acid eliminates pyrogen because of its carbohy- 

 drate nature. 



559. BOROFP, D. A. 



Study on toxins and antigens of Shigella dysenterlae . I. Tox- 

 icity and antigenicity of whole organisms and various fractions 

 of Shigella dysenterlae . 



J. Bact. 57:617-632, 19^9 



Somatic fractions of S. dysenterlae or its "smooth" variant pro- 

 duce identical antibodies and cross reactions with antiserum 

 while the "rough" variant fractionated products do not Induce 

 immunologic reactions. The toxic properties, present in all forms 

 and fractions, are attributable to a single endotoxin, which may 

 consist of a toxic protein, nonantlgenlc, a specific polysacchar- 

 ide. Inducing antibody formation, and a lipoid. 



560. BOROFP, D. A. and MAORI, B. P. 



Study on toxins and antigens of S. dysenterlae . II. Active pro- 

 tection of rabbits with whole organisms and fractions of Shi - 

 gella dysenterlae 



J. Bact. 58:387-39^, 19^9 



Reciprocal protection against homologous strains of S. dysenterlae 

 is afforded by either "smooth" or "rough" whole organisms or 

 their respective toxins. Chemically purified toxins give simi- 

 lar protection. Nontoxic variants give as effective protection 

 as toxic parent strains. The presence of antitoxin or the leth- 

 ality of its toxin are not determining factors in inducing im- 

 munity. 



561. BRUETSCH, W. L. 



Why malaria cures general paralysis 



J. Indiana M. A, 42:211-216, 19^9 



The author revelws the literature on malarial fever therapy and 

 concludes that in the therapy of luetic general paralysis, fever 

 per se is a minor factor. Beneficial results depend upon the 

 kind of fever produced and upon activation of the reticuloendo- 

 thelial system to stimulate production of macrophages. Both 

 malarial and typhoid fevers are most active in producing Intense 

 macrophagic responses. Tissue immunity produced by retlculoendo- 



