- 1 9 4 9 - 



thelial stimulation inhibits spirochetal growth, disintegration 

 and disappearance. Regression and resolution of the inflam- 

 matory processes in the brain follow. "The killing mechanism 

 of the spirochetes in general paralysis. . .must be looked for in 

 antibody production by the R-E cells." Any phagocytosis of 

 spirochetes by malaria organisms or ingestion of pallida by 

 capillary endothelial cells in the brain must be considered un- 

 proven. 



562. BUNTING, M. I., ROBONOW, C, P. and BUNTING, H. 



Factor affecting elaboration of pigment and polysaccharide by 

 Serratia marcescens . 



J. Bact, 58:114-115, 1949 



Capsule formation in A. aerogenes is encouraged when growth of 

 the organism is restricted by excessive carbohydrate in the 

 medium, but deficiencies of N and P. Cells assume a nuclear 

 appearance as ribonucleotide leaves the cytoplasm. The accumu- 

 lation of prodiglosin^ a pyrrole derivatlvej, parallels the ela- 

 boration of polysaccharide in the cell. 



563. CHAMBERS, WW,, KOENIG, H., KOENIG, R, and WINDLE, W. P. 



Site of action in the central nervous system of a bacterial pyro- 

 gen 



Am. J. Physiol. 159:209-216, 19^9 



Febrile response to a bacterial pyrogen from a Pseudomonas species 

 (PYROMEN) appears to be mediated through the central nervous sys- 

 tem, and the cord must be in functional communication with one or 

 more brain centers. Such responses are prevented by transection 

 of the spinal cord in the lower cervical or upper thoracic areas; 

 side reactions were not Inhibited. When transection was made be- 

 low T-5^ the development of fever was not prevented. Decortica- 

 tion, thalamic and caudal hypothalamic lesions do not prevent fe- 

 brile reactions, Decerebratlon at a pontile or medullary level 

 did not prevent fever; an Integrating mechanism appears to exist 

 in the medulla oblongata or the upper spinal cord; connections 

 with the spinal cord below the cervical region renders the or- 

 ganiam fully responsive to pyrexlal agents. 



