199 



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564. CHASIS, H., GOLDRING, W. and BALDWIN, D. S. 



Effects of febrile plasma ^ typhoid vaccine and nitrogen mustard 

 on renal manifestations of human glomerulonephritis 



Proc. Soc. Exper, Biol, & Med. 71:565-56?, 19^9 



No decreases in proteinuria were noted in patients with diffuse 

 glomerulonephritis after repeated intravenous administration of 



plasma taken from febrile 

 streptococcal infections » 

 diuresis. In one patient 

 administration of typhoid 

 filtration rate, but not 



per kg. body weight) reversed the renal 

 ulonephrltls, reducing proteinuria and, 

 creasing urine output. 



patients during pneumococcal and 



Febrile plasma did not Induce 

 V7ith marked renal function impairment, 

 vaccine reduced proteinuria and the 

 inhibition of urine flow. HN2 (0.2 mg. 



manifestations of glomer- 

 in one instance, in- 



CREECH, H. J., HANKWITZ, R. P., JR o and WHARTON, D. R. A» 



Further studies of the immunological properties of polysaccharides 

 from Serratia marcescens ( Bacillus prodlglosus ) . I, The effects 

 of passive and active immunization on the lethal activity of the 

 polysaccharides 



Cancer Res. 9:150-157, 19^9 



In mice bearing dorsal implants of Sarcoma 37, passive immuni- 

 zation with gamma -globulin fractions from serum rendered immune 

 against strains of S_c_ marcescens protected the animal to some 

 extent against the lethal dose of the polysaccharide of the same 

 organism. Active immunization in tumor-bearing mice was accom- 

 plished by the injection of small intraperitoneal doses of the 

 polysaccharide followed by the dose ordinarily lethal to 90^ 

 of test animals. A prolonged tolerance tovi^ard lethal activity 

 of the polysaccharide could be established in both normal and 

 tumor bearing mice, by a single injection of 1 per cent of the 

 90J^ lethal dose of polysaccharide from any of the strains studied. 

 This appears to be a true immunological response. 



566. CREECH, H, J. and HANKWITZ, R, P., JR. 



Further studies of the immunologic properties of 

 from Serratia marcescens ( Bacillus prodlglosus ) . 

 immunization against the lethal activity of the 

 with fractions of mouse antiserum elicited hy a 

 of polysaccharide 



Cancer Res, 9:589-591, 19^9 



polysaccharides 

 III. Passive 

 polysaccharides 

 single injection 



Protective antibodies multiplied rapidly in the serum of mice 



