202 



_ 1 9 4 9 - I 



life of the animal; the carbohydrate may be isolated from body 

 tissues for at least one year after immunization^ and hyper- 

 sensitivity is exhibited toward the type-specific organism. No 

 antibody is produced either toward bacteria or immunizing doses 

 of the polysaccharide. Human beings may become non-reactive 

 toward immunizing doses of polysaccharides from an initial 

 paralyzing reaction. It is postulated that a given antigen may 

 become firmly fixed to cell surfaces of the reticulendothelial 

 tissues and lose capacity to act as an antigen. 



57^. PRANCKENSTEIN, R„ 



Uber die typhosen Erkrankungen in Kindersalter und ihre Behand- 

 lung mit Pyrifer (Enteric fevers in older children: Treatment 

 with pyrifer) 



Medizin. klin. 44:199-203^ 19^9 



Nerve regulatory centers affected by cyclic infection by E. typhi 

 in children produced symptoms which were benefited by the in- 

 jection of pyrifer, 20 to 50 units, intravenously. Temperatures 

 rose in one-half to one hour thereafter, with mild rigors. Other 

 syTiiptoms of a psychotic nature associated with the usual clini- 

 cal picture were seen in 80 children infected by E. typhosa or 

 paratyphi B. Younger children gave most rapid response to pyrl- 

 fer and very slight reactions were followed by excellent results, 

 with very little relation between fever production, onset of 

 chills and the therapeutic result being evident. Pyrifer re- 

 duced temperature elevation in a child, 18 months old, in whom 

 encephalitis, stupor and a roseola appeared after paratyphus 

 infection. 



575. GERMAN, A, 



Pyrogenes (Pyrogens) 



Ann. pharm. franc. 6:464-479, I949 



After reviewing the literature of pyrogenic phenomena and making 

 certain comparisons between the action of known pyrogens and that 

 incidental to vaccinotherapy and "protein shock", the author 

 concludes that pyrogenic reactions may be responsible for bene- 

 fits derived from vaccine injections. It is difficult to explain 

 why antibodies appear after injection of killed bacteria in in- 

 fections in which little antibody formation is developed by the 

 pathogens present „ Shock may be responsible for some beneficial 

 reactions to so-called "protein"substances, but it is noted that 

 superior results followed the use of three strong producers of 

 pyrogen, ie. streptococci, staphylococci and Ps. aeruginosa , in 

 a bacterial preparation (prodidon). The initial leukopenia 

 following the injection of pyrogens and the ensuing leukocytosis 



