203 



-19 4 9- 



raay be brought about by a dual activity in pyrogen: (l) massive 

 liberation of antibody by lymphopenia, and (2) defense reactions 

 by the organism with the release of leukocytes in an effort to 

 combat stress. 



576. GINSBERG, H. S. and HORSFALL, F. L., JR. 



A resistant variant of mumps virus. Multiplication of the var- 

 iant in the presence of inhibitory quantities of Friedlander 

 bacillus polysaccharide 



J. Exper. Med. 90:393-407, 19^9 



A large single inoculum of mumps virus or serial passage of 

 the virus in the presence of inhibitory quantities of capsular 

 polysaccharide of Friedlander bacillus , type B may produce var- 

 iant virus strains, with infective and agglutinative qualities 

 identical with the parent strain, but slower to multiply and not 

 inhibited by polysaccharide. In the absence of the polysacchar- 

 ide, serial passage again produces the original sensitive strain. 



577. GRANT, R. 



Nature of pyrogen fever: Effect of environmental temperature 

 on response to typhoid -paratyphoid vaccine 



Am. J, Physiolo 159:511-523, 19^9 



Oxygen consumption was used as a measure of calorigenesis when 

 intravenous injections of typhoid -paratyphoid vaccine or "Pyrexln" 

 were given to rabbits kept under constant environmental conditions, 

 The amount given was about 100 times the minimal pyrogenic dose. 

 In moderate and warm environments, moderate doses of TPT brought 

 initial temperature increases, a temporary fall in about 1 hour 

 and renewed inhibition of heat loss mechanisms toward the end of 

 the 2nd hour. With very large doses the early course of fever is 

 the same, but pyrexia may be prolonged. With very small doses, 

 initial temperature rises are identical with those produced by 

 larger amounts, but the final rise in temperature begins early. 

 Oxygen consumption during the first hour Is not affected by 

 temperature changes; after the first hour, hypothermia follows 

 in the shorn cold animal. The scant evidence available suggests 

 that pyrogens may interfere with thermoregulation at lower levels 

 of the brain stem^ 



578. GRANT, R. and ROBBINS, M. E. 



Effect of ethyl carbam.ate on temperature regulation 

 Federation Proc. 8:59,1949 



