204 



- 1 9 4 9 - 



Prior or subsequent intravenous Injections of urethane did not 

 alter the inhibition of heat loss mechanisms by bacterial 

 pyrogens; intraperitoneal injections of urethane may allow vaso 

 dilation.^ with polypnea unaffected. 



579. GRANT, R., ROBBINSj M. and HALL^, V. E. 



Effect of environmental temperature on the febrile reaction to 

 typhoid paratyphoid vaccines and other pyrogens 



Am. J. Med. 6:395, 19^9 (Abstract) 



After the intravenous injection of pyrogen, the oxygen pro- 

 duction in the rabbit increases to a maximum during the first 

 20 minutes, and is approximately 15 per cent higher than that 

 of controls for the first hour. It remains slightly above 

 normal during the second and subsequent hours of fever if en- 

 vironmental temperatures remain moderate or warm; when exposed 

 to severe cold, oxygen values show sharp reductions below con- 

 trol values during the second hour and return to normal levels 

 during the third hour. In normal environmental temperatures the 

 second hour after a pyrogen injection brings an inhibition of 

 heat defense mechanisms^ and fever increases are again recorded. 



580. GROSSMAN, M„ I. and BLICKENSTAPF, D, 



Quantitative aspects of inhibition of gastric secretion by 

 pyrogens 



Am. J. Physiol. 159:572, 19^9 (Abstract) 



A lag period between the appearance of pyrexia after intravenous 

 injection of pyrogen and inhibition of gastric secretion has been 

 reported. Another gap exists later in the test between tempera- 

 ture relations and gastric secretion Inhibition. 



581. HALL, V. E., FISHGOLD, J- and GRANT, R. 



Oxygen consumption of liver slices from febrile and normal 

 rabbits 



Federations Proc. 8:66, 19^19 (Abstract) 



If, as suggested, heat production of the liver is increased 

 during fever produced by bacterial pyrogens, measurement of O2 

 consumption in vitro of liver slices taken from rabbits 15 

 minutes after injection of typhoid -paratyphoid vaccine does not 

 confirm such observations. 



