208 



-19 4 9- 



1 



Although continuous Intravenous typhoid vaccine therapy Is practi- 

 cable for adjuvant fever therapy with penicillin, some selection 

 of patients would improve the results obtained in these inves- 

 tigations. The two criteria used were (1) no clinical evidence 

 of cardiovascular disease (2) ages under 50 years. 



595. MARTELLI, P. and NUROLONE.. U. 



La piretoterapia nel trattaraento della paralisi facclale primi- 

 tiva con particolare riferimento alia forma inveterata (Pyreto- 

 therapy in the treatment of primary facial paralysis, with 

 particular reference to chronic cases) 



Minerva med» (Turin) 2:403-4o6, 1949 



In primary idiopathic facial paralysis, but not in secondary 

 manifestations associated with more fundamental causes, bene- 

 fits were secured through use of agents, physical or otherwise, 

 which elevated the temperature. Results would support the hypo- 

 thesis that primary facial paralysis may be of allergic etio- 

 logy^with fever acting, in these improved cases- as anti-aller- 

 gen. 



596. MCGINTY, D, A., WILSON, M. L. and RODNEY^ G. 

 The ulcer-inhibiting action of pyrogens 



Proc. Soc. Exper. BioJ. & Med „ 70:334-336, 1949 



Extracts from urine known to possess pyrogenic activity have 

 inhibited ulcer formation in rats. These observations have 

 been extended to the use of purified substances from cultures of 

 B. prodigiosu s, Ps . aeruginosa and E. typhi , given by vein in 

 0.5 ml. volurae prior to pyloric ligation In the rat, or by 

 stomach tube during the period of recovery from anaesthesia. 

 Pyrogens from B. prodlglosus (3 to 10 gammas) protected iS of 

 23 rats against ulcer (index 72); the index fell to I5 when do- 

 sage levels were raised to 35 or 50 gammas. Intraperitoneal 

 injections were less effective and higher dosages were required 

 (100-1000 gammas). Typhoid pyrogens inhibited ulcer formation 

 in 75^ of the rats under therapy. Ps_. aeruginosa pyrogen was 

 less effective than that secured from cultures of B. prodlglosus . 

 Non-pyrogenic polysaccharides (pneumococcal carbohydrates) had no 

 anti-ulcer acltvity. The mechanism of action by which results 

 are obtained is not clear, but both volume and acidity of gastric 

 secretions appear to be reduced. 



597. MENKIN, V. 



An additional thermostable component in the mechanism of leuko- 

 cytosis with inflammation 



