209 



-19^9- 



Poderation Proc. 3:362, 19^9 



The thermostable, pyrogenic factor, pyrexln, induces the 

 Initial leukopenia. It is found in the euglobulin fraction in 

 the acid exudates of inflammatory processes. A second thermo-^ 

 stable component appears to be in close association with pyrexin 

 and to play a part in the induction of high levels of leukocyte 

 formation. 



598. MORGAN, H. R. and NEVA, P. A. 



Tolerance to the toxic effects of somatic antigens of enteric 

 bacilli in typhoid and paratyphoid fever convalescents, 



J. Clin. Invest. 28:S00, 19^9 (Abstract) 



Intravenous test doses of the endotoxin of S. typhosa (5 mlcro- 

 gram.s) produced no evidences of the marked febrile responses and 

 reactions seen in normal individuals when it was administered to 

 convalescent patients after infections with typhoid or para- 

 typhoid organisms. Shigella dysenteriae (7 micrograms) somatic 

 antigen was not productive of febrile reactions after resistance 

 had developed following spontaneous infections, 



599. MUETHER, R, 0. 



Pyrogens in intravenous solutions 

 Hospital Prog, 30:301, 19^9 



The author briefly reviews the causes of pyrogen reactions and 

 their sources, symptoms and treatment, and the manner in which 

 bloassay of parenteral fluids may be conducted. 



600. NECHELES, H. (Editor) 



21st Annual Report, Med. Res. Institute, Michael Reese Hospital 



19^9 



The observation has been made that even minimal amounts of cer- 

 tain bacterial pyrogens may depress normal functions of the 

 stomach, le. secretion of acid and normal emptiring time. The re- 

 duction of gastric spasm in ulcer conditions might aid healing 

 processes. Doses of pyrogen too minute to produce fever depress 

 secretory activity, and it is tentatively stated that these sub- 

 stances may be responsible for therapeutic results achieved by 

 certain preparations commonly prescribed in ulcer therapy. 



