210 



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 601. OLITZKI, L, 



Anti-leukopenic tolerance of rabbits and antibody formation in 

 the course of treatment with typhoid vaccine 



Acta Med. Orient. 8:103, 19^9 



Tolerance to the leukopenic effects of typhoid vaccine developed 

 in rabbits during treatment and was unrelated to development of 

 antibodies in the blood serum. The tolerance was noted most 

 frequently after intra-abdominal administration. Leukocytes 

 collected in pulmonary areas during the period of leukopenia and 

 were released in the succeeding phase. 



602. OTT, W. H. 



A quantitative assay method for pyrogens 



J. Am. Pharm. A. (Sci, Ed.) 38:179-184, 1949 



When test animals were carefully selected for similarity of re- 

 sponse to a standardized pyrogen (a standard error variation 

 computed on the basis of the assay values in 4 rabbits was found 

 to be minus or plus 6o^) , a method for reducing error was de- 

 veloped, which would greatly increase the number of animals used 

 m assayo The standard error is Inversely proportional to the 

 square of the number of animals used in the assay. The correctioa 

 can be aided further by standardization procedures adapted by 

 each testing laboratory and preparation of dosage-response curves 

 for groups of animals tested under these conditions. 



603. PAGE, I. H. and CORCORAN, A. C. 



"Treatment with Pyrogen." Arterial H ypertens ion. Chicago; The 

 Year Book Publishers, Inc. 2nd Edition, 1949 ;"pp. 328-330 



Thirty-five patients were treated with the pyrogenic agent PYROMEN 

 J- or periods extending from 5 to 19 weeks. A good clinical re- 

 sponse was shown by I9 patients. The most marked difference 

 between Improved and unimproved groups appeared to be the pre- 

 sence of arteriolar sclerosis. Delayed response to pyrogens 

 m both normal and hypertensive patients Involve vasodilatation, 

 particularly in the renal vascular bed. Increased renal blood 

 flow usually persists for 24 to 36 hours after the pyrogenic 

 reaction. In the above group., patients who improved averaged 

 b2 mg, per minute per 1.73 sq, m. body surface as shown by TMPAH 

 readings and only 26 mg. in unimproved patients. Blood pressure 

 was reduced; there was regression of retinal hemorrhage and ab- 

 sorption of retinal exudates. Congestive heart failure resis- 

 tant to therapy improved in five Instances, Immediate hemodynamic 



