211 



_ 1 9 4 9 - 



responses and adrenal plasma and tissue enzyme interrelation- 

 ships may enter into the mechanism of response to pyrogens. For 

 hypertension^ pyrogen treatment must be given under careful 

 supervision; hospitalization is required. 



PAGE, I. H. and TAYLOR, R, D. 



Pyrogens in the treatment of malignant hypertension 



Mod. Concepts Cardiovasc Dis= l8:51, 19^9 



PYROMEN is considered to be the most satisfactory agent in the 

 treatment of malignant hypertension, according to the results 

 evaluated by the authors c Twenty patients have been treated 

 with this agent over a period of four years. All selections for 

 this therapy were based on the presence of renal function ade- 

 quate enough to excrete para-amino hippurate at 35 mg„/"iii^°/l»73 

 sq. m. body surface, or to concentrate urine at specific gravity 

 of 1.020 or above. ' PYROMEN was administered intravenously daily 

 for 5 or 6 days per week. The initial dose was 50 micrograms, 

 successive doses were increased to maintain a temperature rise 

 to 103 or 104° P. each day. When tolerance developed, treatment 

 was discontinued for 3 to 7 days. Of 20 patients so treated, 

 ten survived. Of five who discontinued treatment before re- 

 sults were obtained, 4 died, four patients who exhibited early 

 improvement developed essential hypertension later. Where 

 cardiac decompensation existed PYROMEN therapy appeared to be 

 of value. 



PATTERSON, J. L., HEYMAN, A, and NICHOLS, P. Tc 



Effects of fever induced by bacterial pyrogen on cerebral cir- 

 culation and oxygen consumption 



Am. J. Physiol, 159:584, 1949 (Abstract) 



Cerebral blood flow and oxygen consumption levels were deter- 

 mined in 16 patients with asymptomatic neurosyphilis after intra- 

 venous injections of typhoid vaccine..: Comparisons were made with 

 readings secured during the afebrile state. Cerebral vascular 

 resistance was significantly decreased (average 25.4;^) as the 

 rectal temperature increased to a mean 3.8° P. above previous 

 readings. The blood flow was unchanged. When vascular resis- 

 tance was above the normal in the afebrile state, values were 

 higher. Mean arterial pressure reductions of 2.4^ accompanied 

 cerebral vascular tension decreases. There was a high degree 

 of correlation between^oxygen consumption and cerebral flow 

 during fever, but these levels were unrelated to each other 

 during afebrile periods. 



