i 



214, 



- 1 9 4 9 - 

 613. SELIGMAN, A. M. and SACK, T. 



Chemical alteration of polysaccharide from Serratia marcescens: 

 Reaction of polysaccharide with radioactive paraiodo benzene- — 

 diazonium chloride and use of product in experimental and 

 chemical study 



J. Nat. Cancer Inst„ 10:105-118,. I949 



The preparation of a radioactive iodobenzene azo product is 

 described. Toxicity of the radioactive product was similar 

 to the unmodified polysaccharide of S. marcescens as was shown 

 by changes following the administration of the carbohydrate 

 m three patients with malignant tumors. 



'''• anfE^ETT^M! r'™' "' '" ^''^^' '' ^- ^«^^^> '' ^• 

 Serum polysaccharide levels in experimental inflammation 

 Proc. Soc. Exper. Biol. & Med. 72:294-296, I949 



J^^S^^^^'^v^'^?^^ inflammation, bacterial, or, as in this study, 

 la?ed'hf,t^^ irritant agents such as turpentine or talJ! Tde-' 

 recorded ^^P^^^sive increase in serum polysaccharide was 

 to slv d^... o2r "'f^^"^""^ elevation does not appear until three 

 iLved ?n^L ^^^'^ injury, the role of tissue destruction is be- 

 resDonslble foi^'^h ^^^^n-f^istent . Regenerating tissue may be 

 responsible for the elevation which is independent of tempera - 



^^^* IrS^^R ^«^ R., POSTER, J. v., KELLY, K. H., SHETLAR, C. L. 

 BRYAN, R. S. and EVERETT, M. R. ^ ^. j^. 



ologicarco'ndL'fSns'^'"' ''"'' '" malignancy and in other path- 

 Cancer Res, 9:515-519, 1949 



theTeak^no^Sa^^^i'^f/^^^i" ^^ neoplastic disease are higher than 

 normal lev2^f?;.^''^i^; ^"^ ^^^^^n tumors, no production of ab- 

 skin and Of JhrS "°^!'^' ^^^^^^ ^^^^^ 1°^^^ in carcinoma of the 

 increased ThJ ?™^** ^^^^^ surgical removal blood levels 

 atlon and renp?r. mS^^^^ "^^^ ^® connected with tissue prolifer- 

 chroni? con^f?^n; ^^! ^^""""^ polysaccharide is increased in many 

 norspecl??cal]?^ir^ "^^?^ infectious processes, hence levels are 

 noi; specifically diagnostic for neoplastic disease. 



