216 ^^ 



- 1 9 5 - 



618. ALBOT, G. and BERNARD, BRUKER, N, 



Nouveau traitement des dlarrhees par les emulsions de Bacillus 

 Subtllls (New treatment of diarrhea by emulsions of B. subtilis ) 



Sem, hopit. (Paris) 3^00-3^035 1950 



619. ALTSCHULE, M. D,, PARKHURST, B. H., and PROMISEL, E. 



Effects of intravenous injections 3of typhoid vaccine on blood 

 leukocytes and adrenal cortex 



A.M. A. Arch. Int. Med. 86:505-518, I95O 



When typhoid vaccine was injected intravenously into psychotic 

 patients (6)^ cellular redistribution in blood was observed, 

 with lymphocytes and eosinophils decreased by approximately 80^, 

 and granulocytes increased from 50 to 200^ after each treatment. 

 The lymphocyte count returned to normal after three days. No 

 correlation with the degree of fever produced could be measured. 

 Electirc shock therapy did not produce such startling changes 

 (eosinophils decrreased 48^, lymphocytes but l6^) . Changes in 

 the urinary output of 17-ketosteroids were seen. Urine uric 

 acid: creatinine ratios varied inversely to the degree of 

 vaccine fever, 



620. ARENDSHORST, W. and FALLS, H. P. 



Role of the adrenal cortex in treatment of ocular diseases with 

 pyrogenic substances 



A.M. A. Arch. Ophth. 44:635-642, I95O 



This study was planned to determine the effects of "protein 

 shock therapy in ocular disease and as an investigation of the 

 possible release of 11, 17-oxysteroids from the adrenal cortex. 

 The circulating eosinophil response to injections of the antigen 

 was taken as the most sensitive index of cortical activity. 

 Typhoid H antigen was used as a "foreign" protein, and in 

 dosages ranging from I5 to 25 million units initially to higher 

 concentrations, was administered to patients with various uveal 

 diseases. 



Correlation was noted between eosinopenia, fever and the general 

 response to the pyretogenic agent. Six of 21 patients had poor 

 eoslnopenic responses and proved to be resistant to foreign 

 protein shock". Drop in eosinophils usually occurred about I8 

 hours following injection;.. Improvement in ocular tissues was 

 seen in 14 patients. The effects of pyretotherapy were attri- 

 buted by the authors to the initiation of an "alarm" reaction 

 and succeeding stimulation of the adrenal cortex, but no .satis- 

 factory explanation for the mechanism involved could be produced. 



